Results 101 to 110 of about 6,046,760 (380)

Lensing Measurements of the Mass Distribution in SDSS Voids

open access: yes, 2015
We measure weak lensing mass profiles of voids from a volume-limited sample of SDSS Luminous Red Galaxies (LRGs). We find voids using an algorithm designed to maximize the lensing signal by dividing the survey volume into 2D slices, and then finding ...
Clampitt, Joseph, Jain, Bhuvnesh
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Enhanced Core Formation Rate in a Turbulent Cloud by Self-gravity

open access: yes, 2010
We performed a numerical experiment designed for core formation in a self-gravitating, magnetically supercritical, supersonically turbulent, isothermal cloud.
Cho, Wankee, Kim, Jongsoo
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Second moment of the Husimi distribution as a measure of complexity of quantum states

open access: yes, 2001
We propose the second moment of the Husimi distribution as a measure of complexity of quantum states. The inverse of this quantity represents the effective volume in phase space occupied by the Husimi distribution, and has a good correspondence with ...
A. Boros   +14 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Thermal Conductivity Characteristics of Thermal Insulation Materials Immersed in Water for Cold-Region Tunnels

open access: yesAdvances in Materials Science and Engineering, 2020
This study investigates the distribution of pore water on the basis of the measured mass moisture content after soaking the tunnel insulation material. This study also analyzes the influence of the distribution of pore water on the thermal conductivity ...
Youyun Li   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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