Results 111 to 120 of about 2,180,608 (342)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
, 2015 In the Eulerian approach, the motion of an incompressible fluid is usually described by the velocity field which is given by the Navier--Stokes system. The velocity field generates a flow in the space of volume-preserving diffeomorphisms.
Nersesyan, Vahagn
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Advances in Pore-Scale Simulation of Oil Reservoirs
Energies, 2018 At the high water cut stage, the residual oil in a reservoir becomes complex and dispersed. Moreover, it is challenging to achieve good predictions of the movement of oil and water in a reservoir according to the macroscopic models based on the statistic
Junwei Su +4 more
doaj +1 more source
The role of plasma volume and fluid overload in the tolerance to ultrafiltration and hypotension in hemodialysis patients. [PDF]
Ren Fail, 2023 Ramos-Gordillo JM +3 more
europepmc +1 more source
A volume-of-fluid method for interface-resolved simulations of phase-changing two-fluid flows [PDF]
Journal of Computational Physics, 2019 Nicolò Scapin, P. Costa, L. Brandt
semanticscholar +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Simulation of Slag Droplet Entrainment by Volume of Fluid and Lagrangian Particle Tracking Coupled Modeling. [PDF]
ACS Omega, 2023 Li L, Wei G, Zhu Z, Li B.
europepmc +1 more source