Results 91 to 100 of about 1,475,070 (295)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Petroleum Exploration and DevelopmentAn optimization method of fracturing fluid volume strength was introduced taking well X-1 in Biyang Sag of Nanxiang Basin as an example. The characteristic curves of capillary pressure and relative permeability were obtained from history matching between
Tingxue JIANG +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Perfect Fluid Quantum Anisotropic Universe: Merits and Challenges
, 2012 The present paper deals with quantization of perfect fluid anisotropic cosmological models. Bianchi type V and IX models are discussed following Schutz's method of expressing fluid velocities in terms of six potentials.
AB Batista +19 more
core +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Aluminium extrusion analysis by the finite volume method [PDF]
, 2013 Present work proposes a novel numerical scheme to calculate stress and velocity fields of metal flow in axisymmetric extrusion process in steady state.
Bressan, Jose D. +2 more
core
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
SIMULATIONS OF THE WATER FREEZING PROCESS – NUMERICAL BENCHMARKS
TASK Quarterly, 2003 Three numerical benchmarks concerning the freezing of water in small enclosures are analysed using the commercial FLUENT code. The first case is a steady-state natural convection in a differentially heated cavity for temperatures near the freezing point.
TOMASZ MICHAŁEK, TOMASZ A. KOWALEWSKI
doaj
Pore-scale Modeling of Viscous Flow and Induced Forces in Dense Sphere Packings
, 2013 We propose a method for effectively upscaling incompressible viscous flow in large random polydispersed sphere packings: the emphasis of this method is on the determination of the forces applied on the solid particles by the fluid.
A.V. Oostreom +36 more
core +1 more source