Results 91 to 100 of about 1,475,677 (295)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Numerical simulation of fluid–structure interaction with the volume penalization method

Journal of Computational Physics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Thomas Engels, Dmitry Kolomenskiy, Kai Schneider, Jörn Sesterhenn   +3 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Material Transport under a Wave Train in Interaction with Constant Wind: A Eulerian RANS Approach Combined with a Lagrangian Particle Dispersion Model

Fluids, 2018
The interaction of a developed train of gravity deep water waves with suddenly applied winds is investigated in this manuscript. The direction of the wind is the same as that of the wave train (i.e., following) and its imposed surface shear stress is ...
Nityanand Sinha, Roozbeh Golshan
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Temperature induced pore fluid pressurization in geomaterials [PDF]

, 2010
The theoretical basis of the thermal response of the fluid-saturated porous materials in undrained condition is presented. It has been demonstrated that the thermal pressurization phenomenon is controlled by the discrepancy between the thermal expansion ...
Ghabezloo, Siavash, Sulem, Jean
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Optimization method of fracturing fluid volume intensity for SRV fracturing technique in shale oil reservoir based on forced imbibition: A case study of well X-1 in Biyang Sag of Nanxiang Basin, China

Petroleum Exploration and Development
An optimization method of fracturing fluid volume strength was introduced taking well X-1 in Biyang Sag of Nanxiang Basin as an example. The characteristic curves of capillary pressure and relative permeability were obtained from history matching between
Tingxue JIANG, Ziqi SHEN, Liangjun WANG, Zili QI, Bo XIAO, Qiuping QIN, Xiqun FAN, Yong WANG, Hai QU   +8 more
doaj   +1 more source

Perfect Fluid Quantum Anisotropic Universe: Merits and Challenges

, 2012
The present paper deals with quantization of perfect fluid anisotropic cosmological models. Bianchi type V and IX models are discussed following Schutz's method of expressing fluid velocities in terms of six potentials.
AB Batista, Barun Majumder, BF Schutz, BF Schutz, Bryce S DeWitt, Charles W Misner, CJ Isham, FG Alvarenga, FG Alvarenga, FI Cooperstock, JM Nester, KV Kuchar, KV Kuchar, N Banerjee, N Rosen, NA Lemos, Narayan Banerjee, SW Hawking, VG Lapchinskii, WW Bell   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source