Results 101 to 110 of about 2,102,324 (339)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Fluid consumption, exercise, and cognitive performance

Biology of Sport, 2016
Laboratory evidence supports the notion that dehydration degrades exercise performance and impairs certain cognitive processes. The purpose of this study is to examine the effect of a voluntary versus a dictated drinking condition on exercise and ...
TP Backes, K Fitzgerald
doaj   +1 more source

Mozambican Civil Society Within: Evaluation, Challenges, Opportunities and Action [PDF]

, 2007
The aim of this ambitious venture is to evaluate the main dimensions of civil society's exercise of citizenship: a) its organisational Structure, covering its free and voluntary involvement, participation and contribution to society; b) the socio ...
Albertina Mucavele, António Francisco, Paula Monjane, Sónia Seuane   +3 more
core  

Muscle fiber conduction velocity is more affected after eccentric than concentric exercise

, 2011
It has been shown that mean muscle fiber conduction velocity (CV) can be acutely impaired after eccentric exercise. However, it is not known whether this applies to other exercise modes.
A Michaut, AL Hodgkin, Alberto Botter, AN Belcastro, B Bigland, B Katz, BE Flucher, BS Pallotta, BT Corona, C Juel, CT Davies, DA Jones, DA Jones, DJ Newham, DL Morgan, E Stalberg, F Bonde-Petersen, F Burton, G Sjogaard, GL Warren, GW Kroon, H Piitulainen, H Piitulainen, H Takekura, Harri Piitulainen, IC Smith, Janne Avela, K Nosaka, K Vijayan, KC McGill, LK McFadden, N Babault, P Sbriccoli, PA Merton, PL McNeil, PM Clarkson, PM Clarkson, PV Komi, R Merletti, R Merletti, RB Armstrong, RH Edwards, RL Lieber, RL Ruff, RL Ruff, Roberto Merletti, SF Street, SH Westing, T Clausen, T Hortobagyi, T Masuda, TA McBride, TC Chen, V Linnamo, WT Stauber, WT Stauber   +55 more
core   +1 more source

Screening elite winter athletes for exercise induced asthma: A comparison of three challenge methods [PDF]

, 2005
The official published version can be obtained from the link below.Background: The reported prevalence of exercise induced asthma (EIA) in elite winter athletes ranges from 9% to 50%. Many elite winter athletes do not report symptoms of EIA.
Dickinson, JW, Harries, MG, McConnell, AK, Whyte, GP   +3 more
core   +2 more sources

Dopaminergic Genetic Variants and Voluntary Externally Paced Exercise Behavior [PDF]

Medicine & Science in Sports & Exercise, 2018
Most candidate gene studies on the neurobiology of voluntary exercise behavior have focused on the dopaminergic signaling pathway and its role in the mesolimbic reward system. We hypothesized that dopaminergic candidate genes may influence exercise behavior through additional effects on executive functioning and that these effects are only detected ...
Van Der Mee, Denise J., Fedko, Iryna O., Hottenga, Jouke Jan, Ehli, Erik A., Van Der Zee, Matthijs D., Ligthart, Lannie, Van Beijsterveldt, Toos C.E.M., Davies, Gareth E., Bartels, Meike, Landers, Joseph G., De Geus, Eco J.C.   +10 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Voluntary Exercise Prevents Hypertensive Response Sensitization (HTRS)

The FASEB Journal, 2019
Exercise training has profound effects on the renin‐angiotensin system (RAS), inflammatory mediators and ROS production, all of which influence autonomic nervous system activity and regulates cardiovascular function in both physiological and pathophysiological states.
Baojian Xue, Terry G Beltz, Fang Guo, Alan Kim Johnson   +3 more
openaire   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source