Results 241 to 250 of about 2,102,324 (339)

A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise. [PDF]

Mol Neurobiol
Methi A, Islam MR, Kaurani L, Sakib MS, Krüger DM, Pena T, Burkhardt S, Liebetanz D, Fischer A.   +8 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Voluntary exercise improves hypothalamic and metabolic function in obese mice.

Journal of Endocrinology, 2016
B. Laing, K. Do, T. Matsubara, D. Wert, Michael J Avery, Erin M. Langdon, D. Zheng, Hu Huang   +7 more
semanticscholar   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption. [PDF]

Biomedicines
Nelson CA, Brundage JN, Williams BM, Baldridge JK, Stockard AL, Bassett CH, Burger BJ, Gunter BT, Payne AJ, Yorgason JT, Steffensen SC, Bills KB.   +11 more
europepmc   +1 more source

Reducing the time interval between concussion and voluntary exercise restores motor impairment, short‐term memory, and alterations to gene expression

European Journal of Neuroscience, 2016
R. Mychasiuk, Harleen Hehar, Irene Ma, Sydney Candy, M. Esser   +4 more
semanticscholar   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Methylome-proteome integration after late-life voluntary exercise training reveals regulation and target information for improved skeletal muscle health. [PDF]

J Physiol
Chambers TL, Dimet-Wiley A, Keeble AR, Haghani A, Lo WJ, Kang G, Brooke R, Horvath S, Fry CS, Watowich SJ, Wen Y, Murach KA.   +11 more
europepmc   +1 more source

Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats.

Physiology International, 2016
V. Ghorbanzadeh, M. Mohammadi, G. Mohaddes, H. Dariushnejad, L. Chodari, Shima Mohammadi   +5 more
semanticscholar   +1 more source

Biohybrid Tendons Enhance the Power‐to‐Weight Ratio and Modularity of Muscle‐Powered Robots

Advanced Science, EarlyView.
Biohybrid robots powered by skeletal muscle actuators are capable of dynamically adapting to environmental cues. This study takes inspiration from native muscle–tendon architecture by leveraging tough hydrogels as synthetic tendons for muscle actuators to enhance the power‐to‐weight ratio and modularity of biohybrid machines.
Nicolas Castro, Ronald Heisser, Maheera Bawa, Bastien Aymon, Sarah Wu, Annika Marschner, Sonika Kohli, Angel Bu, Laura Rosado, Martin Culpepper, Xuanhe Zhao, Ritu Raman   +11 more
wiley   +1 more source