Results 71 to 80 of about 9,530,886 (208)

von Hippel-Lindau Disease: an Update

Current Genetic Medicine Reports, 2019
AbstractPurpose of ReviewIn this review, we discuss the key molecular and clinical developments in VHL disease that have the potential to impact on the natural history of the disease and improve patient outcomes.Recent FindingsIdentifiable mutations inVHLunderlie most cases of VHL and define clear genotype-phenotype correlations.
Maher, Eamonn, Sandford, Richard
openaire   +2 more sources

Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática

Oncología
Background: Von Hippel-Lindau disease is an autosomal dominant syndrome characterized by the development of benign and malignant tumors throughout life.
Veronica Hurtado Hurtado, Cristina Cabrera Mañay, Patricia Tamayo Aguilar   +2 more
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

The Endothelial Landscape and Its Role in Von Hippel–Lindau Disease

, 2021
Von Hippel–Lindau disease (VHL) is a rare hereditary disease characterized by the predisposal to develop different types of highly vascularized tumors.
Rojas-P, Isabel de, Taranets, Lyudmyla, Lucía Recio-Poveda, Virginia Albiñana, Thales Kronenberger, Popov, Nikita, Isabel de Rojas-P, Angel M. Cuesta, Botella, Luisa María, Lyudmyla Taranets, Botella, Luisa M., Nikita Popov, Albiñana, Virginia, Kronenberger, Thales, Rojas-P., Isabel de, Cuesta, Ángel M., Cuesta Martínez, Ángel, Luisa M. Botella, Recio-Poveda, Lucía   +18 more
core   +1 more source

Combined Pancreatic Endocrine Tumor and Serous Cystadenoma

Journal of the Formosan Medical Association, 2009
Pancreatic serous cystadenomas account for 1–2% of all exocrine pancreatic tumors, and endocrine tumors account for 1–2% of all pancreatic neoplasms. The combination of pancreatic serous cystadenoma and endocrine tumor is even rarer.
Min-Shu Hsieh, Kao-Lang Liu, Yu-Wen Tien, Chia-Tung Shun   +3 more
doaj   +1 more source

Spinal Hemangioblastomas in Von Hippel-Lindau Disease Mimicking a Spinal Dural Arteriovenous Fistula

Global Spine Journal, 2014
Introduction Spinal hemangioblastomas (HBs) are rare tumors that are closely associated with a diagnosis of Von Hippel-Lindau disease (VHL). A tissue diagnosis is needed to make the diagnosis of HB because many other entities can present similarly, which
J. Kalyvas, S. Change
doaj   +1 more source

Cerebellar Hemangioblastoma and Von Hippel-Lindau Disease

Pediatric Neurology Briefs, 2002
Six pediatric patients with cerebellar hemangioblastoma were screened for germline or somatic mutations of the von Hippel-Landau gene, in a study at Stanford University Medical Center, Palo Alto, CA.
J. Gordon Millichap
doaj   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

Von Hippel Lindau Disease

, 1976
Von Hippel Lindau Disease with a mini retinal tumor. Pair with R1_C4b. Anatomy: Retina. Pathology: Hemangioblastoma. Disease/Diagnosis: Von Hippel Lindau disease. Clinical: No visual symptoms. Imaging: Flourescien angiogram in R1_C4b.IC-E2ciii-von-hippel-
William F. Hoyt, MD
core  

MR Imaging Findings of Supratentorial Meningeal Hemangioblastoma: A Case Report

대한영상의학회지, 2016
Hemangioblastomas account for 1.1–2.5% of intracranial neoplasms. These tumors most commonly occur in the cerebellum. A 77-year-old woman had a hemangioblastoma, which showed the supratentorial meningeal mass without any history of von Hippel-Lindau ...
Gi Hong Kim, Ho Kyu Lee, Myeong Ju Koh, Young Hee Maeng   +3 more
doaj   +1 more source