Results 81 to 90 of about 9,097,505 (214)
, 2001 Review on Von Hippel-Lindau, with data on clinics, and the genes ...
Richard, S
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Drug Development Research, Volume 87, Issue 6, September 2026.ABSTRACT SND1 is an oncoprotein found to be overexpressed in breast cancer, especially in triple‐negative breast cancer(TNBC). In our previous study, a novel SND1‐interacting peptide 4‐2 was identified, exhibiting cytotoxicity to TNBC cells by inducing SND1 degradation.
Qiqi Wang +5 more
wiley +1 more source
MR Imaging Findings of Supratentorial Meningeal Hemangioblastoma: A Case Report
대한영상의학회지, 2016 Hemangioblastomas account for 1.1–2.5% of intracranial neoplasms. These tumors most commonly occur in the cerebellum. A 77-year-old woman had a hemangioblastoma, which showed the supratentorial meningeal mass without any history of von Hippel-Lindau ...
Gi Hong Kim +3 more
doaj +1 more source
Von Hippel-Lindau Disease: Familial Symptom Clusters
Pediatric Neurology Briefs, 1991 The clinical manifestations and prevalence of von Hippel-Lindau syndrome (HLS) were reported from the Department of Medicine, Albert-Ludwigs-Universitat, Freiburg im Breisgau, Germany, and Department of Pathology, University of Zurich, Switzerland.
J Gordon Millichap
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IJU Case Reports, Volume 9, Issue 5, September 2026.ABSTRACT Background Belzutifan, a hypoxia‐inducible factor 2α (HIF‐2α) inhibitor, is effective for metastatic renal cell carcinoma (mRCC), although its cardiovascular safety profile remains unclear. Case Presentation A 52‐year‐old woman with mRCC developed progressive dyspnea and a 6.7‐kg weight gain 27 days after initiating belzutifan as third‐line ...
Hikaru Kimura +9 more
wiley +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
, 1998 Review on Von Hippel-Lindau, with data on clinics, and the genes ...
Capodano, AM
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My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley +1 more source
Stem Cell ResearchVHL disease is an inherited and autosomal dominant disorder affecting 1 in 36,0000 individuals worldwide. It is caused by von Hippel-Lindau (VHL) gene mutations and can affect both genders and all ethnic backgrounds (Nordstrom-O’Brien et al., 2009; Maher,
Liani G. Devito +9 more
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MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source