Results 81 to 90 of about 9,530,886 (208)

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Von Hippel Lindau Disease

, 1970
Von Hippel Lindau Disease. Retinal photograph showing small whitish hemangiomablastoma. Note the dilated arterial and venous channels entering and leaving the tumor. Anatomy: Retina. Pathology: Hemangioblastoma.
William F. Hoyt, MD
core  

Generation of TWO iPSC lines (CRICKi009-A; CRICKi010-A) from patients with type 1 von Hippel-Lindau (VHL) and histopathologically confirmed renal cell carcinoma (RCC)

Stem Cell Research
VHL disease is an inherited and autosomal dominant disorder affecting 1 in 36,0000 individuals worldwide. It is caused by von Hippel-Lindau (VHL) gene mutations and can affect both genders and all ethnic backgrounds (Nordstrom-O’Brien et al., 2009; Maher,
Liani G. Devito, Eugénie S. Lim, Samuel M. O’Toole, Scott T.C. Shepherd, Daqi Deng, Hugang Feng, Taja Barber, William M. Drake, Samra Turajlic, Lyn Healy   +9 more
doaj   +1 more source

Genetic testing considerations for hereditary duodenopancreatic neuroendocrine tumors

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract The incidence of duodenal and pancreatic neuroendocrine tumors (dpNETs) has increased substantially in recent years. These tumors may be due to syndromic hereditary predisposition syndromes: multiple endocrine neoplasia type 1 (MEN1) or 4 (MEN4), Von Hippel–Lindau disease (VHL), neurofibromatosis type 1 (NF1), or tuberous sclerosis complex ...
Théo Charnay, Camille Giannetti, Nicolas Sahakian, Magalie Haissaguerre, Sandrine Oziel‐Taieb, Veronique Mari, Olivier Gilly, Pauline Vital, Isabelle Raingeard, Bénédicte Découdier, Alexandre Astier, Thomas Cuny, Pauline Romanet, Anne Barlier   +13 more
wiley   +1 more source

Von Hippel Lindau Disease (Retinal Hemangioblastoma)

, 1992
Von Hippel Lindau Disease with large retinal hemangioblastoma. Continued view of the arteriole and venous channels leading to the tumor. Group with R1_C3a, R1_C3c, R1_C3d. Anatomy: Retina. Pathology: Hemangioblastoma. Disease/Diagnosis: Von Hippel Lindau
William F. Hoyt, MD
core  

Limiting Trial‐and‐Error: Linker‐Based 2D Descriptor Analysis to Support Very Early Proteolysis‐Targeting Chimeras Design

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Can simple linker descriptors guide PROTAC design? Analysis of matched CRBN‐ and VHL‐recruiting degraders shows that basic 2D linker properties may capture trends linked to degradation efficiency, in vitro ADME and physicochemical properties. A practical approach to reduce trial‐and‐error in early targeted protein degradation programs. Targeted protein
Giulia Apprato, Serena Traversa, Giulia Caron, Giuseppe Ermondi   +3 more
wiley   +1 more source

Von Hippel Lindau Disease with Photocoagulation Effect

, 1976
Von Hippel Lindau Disease with appearance of Xenon photocoagulation on a mini hemangioblastoma. Anatomy: Retina. Pathology: Hemangioblastoma. Disease/Diagnosis: Von Hippel Lindau disease.
William F. Hoyt, MD
core  

Von Hippel Lindau Disease (Hemangioblastoma of the Optic Disc)

, 1977
Von Hippel Lindau Disease with a retinal hemangioblastoma on her optic disc. Anatomy: Optic disc. Pathology: Hemangioblastoma. Disease/Diagnosis: Von Hippel Lindau disease. Clinical: No visual symptoms. Patient had cerebellar ataxia.
William F. Hoyt, MD
core  

Von Hippel Lindau Disease (Retinal Hemangioblastoma)

, 1984
Von Hippel Lindau Disease (Retinal Hemangioblastoma); Small hemangioblastoma on the disc margin at 10:00. Large peripheral hemangioblastoma out of view to the top right seen on R1_C2b. Anatomy: Optic disc. Pathology: Hemangioblastoma.
William F. Hoyt, MD
core