ABSTRACT Thrombocytopenia and leukopenia are among the most common hematological abnormalities in patients with chronic liver disease (CLD), particularly among those with cirrhosis. Thrombocytopenia and leukopenia are associated with increased risks of bleeding, infection, treatment delay, and poor clinical outcomes.
Xiaoxiao Wang +3 more
wiley +1 more source
A multi-readout photonic sensor for rapid diagnosis of Von Willebrand disease. [PDF]
Butt JN +8 more
europepmc +1 more source
PERCC1‐associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide
Abstract Congenital diarrheas and enteropathies (CODE) are rare inherited disorders characterized by early‐onset intractable diarrhea. Though progress has been made in elucidating the genetic basis of CODE, much remains to be discovered. Another challenge is the lack of curative therapies—treatment is primarily supportive including enteral and ...
Angela Tran, Vivien Nguyen, Phuong Huynh
wiley +1 more source
Pregnancy outcomes in women with Von Willebrand disease: a statewide cohort study. [PDF]
Lim MY +3 more
europepmc +1 more source
Nanofibrous Platforms for Advanced Wound Therapeutics: Mechanisms, Materials, and Clinical Horizons
The fabrication of nanofiber dressings from diverse natural and synthetic polymers offers a robust platform for chronic wound management. By encapsulating therapeutic drugs and bioactive agents, these dressings can simultaneously attenuate chronic inflammation and microbial infection while actively stimulating angiogenesis, addressing the primary ...
Wanho Cho, Chungmo Yang, Hyuk Sang Yoo
wiley +1 more source
Beyond a century of discovery: the global and persistent burden of underdiagnosis in von Willebrand disease. [PDF]
Seidizadeh O +3 more
europepmc +1 more source
Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom [PDF]
Arita +74 more
core +2 more sources
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Gynecologic and obstetric management of girls and women with von Willebrand disease. [PDF]
Abdul-Kadir R, Ragni MV.
europepmc +1 more source
Optimal 1TEL–target protein linker character is target protein‐dependent
In this study, we examine the effect of short to medium‐length flexible, semi‐flexible and rigid linkers on the crystallization of a DARPin or the TNK1 UBA domain fused to the 1TEL protein crystallization chaperone, demonstrating that while rigid linkers can impair crystallization and reduce diffraction quality, the ideal linker character remains ...
Maria J. Pedroza Romo +22 more
wiley +1 more source

