Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
The Role of ABO Blood Type in Thrombosis Scoring Systems [PDF]
, 2017 In addition to their major role in transfusion medicine, there is increasing evidence that ABO blood group antigens (complex carbohydrate molecules widely expressed on the surface of red blood cells and several other cell types) are implicated in the ...
Catalano, Liviana +5 more
core +1 more source
Medicine, 1997 Considerable progress has been made in characterizing the specific molecular defects responsible for the heterogeneous disorder known as von Willebrand disease (VWD). A large number of molecular defects have been identified and precise characterization may now be possible in the majority of type 2A, type 2B, type 2N, and potentially also type 3 VWD ...
William C. Nichols, David Ginsburg
openaire +2 more sources
Closing the gap – detection of clinically relevant von Willebrand disease in emergency settings through an improved algorithm based on rotational Thromboelastometry [PDF]
, 2019 Background Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation ...
Breuer, G. +5 more
core +2 more sources
Migraine and vascular disease biomarkers: A population-based case-control study. [PDF]
, 2018 Background The underpinnings of the migraine-stroke association remain uncertain, but endothelial activation is a potential mechanism. We evaluated the association of migraine and vascular disease biomarkers in a community-based population.
Ferrari, Michel D. +9 more
core +2 more sources
Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists [PDF]
, 2014 Recent experimental evidence suggested that the synthetic peptide desmopressin (DDAVP) interferes tumor angiogenesis by inducing the formation of angiostatin.
Alonso, Daniel Fernando, Garona, Juan
core +1 more source
Endothelial dysfunction and inflammation in asymptomatic proteinuria [PDF]
, 2003 Background. Proteinuria is associated with vascular risk and a systemic increase in vascular permeability. Endothelial dysfunction occurs early in atherosclerosis and modulates vascular permeability. Vascular risk and chronic inflammation are associated.
Adams +67 more
core +1 more source
Dental management considerations for the patient with an acquired coagulopathy. Part 1: Coagulopathies from systemic disease [PDF]
, 2003 Current teaching suggests that many patients are at risk for prolonged bleeding during and following invasive dental procedures, due to an acquired coagulopathy from systemic disease and/or from medications.
A Barber +90 more
core +1 more source
High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells [PDF]
, 2015 Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases.
Aswin, S. (Soedjono) +3 more
core +2 more sources
Mechanochemistry: Fundamental Principles and Applications
Advanced Science, EarlyView.In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong +4 more
wiley +1 more source