Results 11 to 20 of about 151,232 (337)
Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]
Journal of Medical Biochemistry, 2021 Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika +6 more
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von Willebrand's disease [PDF]
European Journal of Haematology, 1975 The common inheritable hemorrhagic disorder, von Willebrand's disease, has been known for only about 50 yr. During these years it has been well established that the cause of the disease is a deficiency of a plasma protein with remarkable biological properties. Future research should focus on details of the molecular structure of this protein.
L, Holmberg, I M, Nilsson
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Romanian Journal of Pediatrics, 2009 Described by Erik Adolf von Willebrand in 1926, it is a constitutional hemorrhagic disease, inherited in the autosomal mode. Considered initially as a thrombopathic disease, then as a prologation of the bleeding time associated to a defi cit in the ...
Valeriu Popescu, Andrei Zamfirescu
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The Pan African Medical Journal, 2021 INTRODUCTION: von Willebrand Disease (vWD) is the most prevalent bleeding disorder. Women are more likely to manifest abnormal bleeding symptoms due to physiologic events and menorrhagia is the most common presenting symptom.
Miyoba Melinda Munsanje +6 more
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Pediatrics In Review, 2014 Von Willebrand disease (VWD) is an inherited defect of blood coagulation that may cause excessive bleeding.
Stacy, Cooper, Clifford, Takemoto
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Genetics in Medicine, 2011 von Willebrand disease is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral cavity bleeding, menorrhagia, bleeding after dental extraction, surgery, and/or childbirth, and in severe cases, bleeding into joints and soft tissues.
Paula D, James, Anne C, Goodeve
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Haematologica, 2020 We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone +3 more
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New developments in von Willebrand disease
British Journal of Haematology, 2020 Von Willebrand disease (VWD) constitutes the most common inherited human bleeding disorder. It is associated with a mucocutaneous bleeding phenotype that can significantly impact upon quality of life.
Helen Fogarty +2 more
semanticscholar +1 more source
Haematologica, 2011 Background Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases.Design and Methods We report an altered splicing process induced by a silent
Viviana Daidone +6 more
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Journal of Thrombosis and Haemostasis, 2020 Type 3 von Willebrand's disease (VWD) patients present markedly reduced levels of von Willebrand factor and factor VIII. Because of its rarity, the bleeding phenotype of type 3 VWD is poorly described, as compared to type 1 VWD.
A. Tosetto +34 more
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