Results 221 to 230 of about 157,236 (308)

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source

Managing Anesthesia for a Patient With Von Willebrand Disease: A Case Report. [PDF]

Cureus
Singavarapu J, Borodulina G.
europepmc   +1 more source

Pulsed Electric Field Processing Enhances the Endothelial Bioefficacy of Red Beet (Beta vulgaris L.) Extracts by Restoring Endothelial Nitric Oxide Synthase–Nitric Oxide Signaling in High‐Fat Diet Rats

eFood, Volume 7, Issue 4, August 2026.
Pulsed electric field (PEF) processing qualitatively reshapes the phytochemical profile of red beet extracts, resulting in enhanced endothelial bioefficacy. Compared with conventional extraction, PEF‐treated extracts more effectively restore nitric oxide signaling, suppress endothelial inflammation, and normalize vascular structure in high‐fat diet ...
Eunju Jang, Tae‐Baek Lee, Lisa Tonini, Soobin Choi, YoonA Jeon, Taehyun Kim, Taeyoung Kang, Hyuk‐Joon Choi, Changhwan Ahn   +8 more
wiley   +1 more source

Allele-selective disruption of pathogenic VWF variants in type 2 von Willebrand disease using CRISPR/Cas9. [PDF]

Blood Adv
Bär I, Groten SA, Barraclough A, Bürgisser PE, van Kwawegen C, Lenting PJ, van Moort I, Eikenboom JCJ, Leebeek FWG, Voorberg J, van den Biggelaar M, Bierings R.   +11 more
europepmc   +1 more source

Development of an ultrasound‐guided fascia iliaca compartment block programme for hip fracture analgesia in the accident and emergency department: A model from north lantau hospital

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 4, August 2026.
Abstract Background Patients with hip fracture presenting at accident and emergency department (AED) of North Lantau Hospital (NLTH) require transfer to a tertiary centre, and the repeated bed transfers involved are painful to the patients. Ultrasound‐guided fascia iliaca compartment block (FICB) is a regional anaesthetic technique for effective opioid‐
Man Ting Lau, Tin Man Hui, Oi Fung Wong, Shing Ko, Wai Ling Irene Lo, Kin Fai Khu, Sing Hing Choi, Yee Ngor Tsui, Yuen Sum Wong   +8 more
wiley   +1 more source

Rewriting the script: gene therapy and genome editing for von Willebrand Disease. [PDF]

Front Genome Ed
Barraclough A, Bär I, van Duijl T, Fijnvandraat K, Eikenboom JCJ, Leebeek FWG, Bierings R, Voorberg J, Trasanidou D.   +8 more
europepmc   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Conservative Management of Hemoperitoneum Due to a Ruptured Hemorrhagic Ovarian Cyst in Type 3 von Willebrand Disease. [PDF]

Cureus
Mahfoud H, Laaboudi R, Elkhorassani M, Elachhab N, Bargach S.   +4 more
europepmc   +1 more source

Shear‐Activated von Willebrand Factor Captures Extracellular Vesicles to Promote Platelet Activation and Metastasis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Under shear flow, stretched vWF captures platelets and EVs, and TF‐positive EVs amplify platelet activation and aggregation. Although tumour cells do not bind vWF directly, the resulting microthrombi trap circulating tumour cells and promote metastatic progression.
Yuanyuan Wang, Xiaobo Liu, Pascal Nakielski, Katrin Nekipelov, Amanda Salviano‐Silva, Alper Topuz, Alexander T. Bauer, Julian Kött, Jannis Akrivakis, Santra Brenna, Tomasz Downar, Neus Feliu, Gerd Bendas, Berta Puig, Stefan W. Schneider, Dmitry A. Fedosov, Christian Gorzelanny   +16 more
wiley   +1 more source

Immune Thrombocytopenia and Type 1 von Willebrand Disease in a Patient With a Femoral Fracture: A Case Report. [PDF]

Cureus
Ferreira A, Roberto A.
europepmc   +1 more source