Stabilization of the Antihemophilic Factor (VIII :AHF) by the Von Willebrand Factor (VIII :VWF): A Possible Model for Von Willebrand’s Disease [PDF]
, 1977 Harvey J. Weiss +2 more
openalex +1 more source
Haemophilia, EarlyView.ABSTRACT Background Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); very few have focused on the Afro‐Caribbean population. Objectives To determine the genotypic and phenotypic characterization of VWD in a large cohort of Afro‐Caribbean patients living in Martinique.
Marie‐Daniéla Dubois +21 more
wiley +1 more source
Inherited Bleeding Disorders in Iraq and Consanguineous Marriage
International Journal of Hematology-Oncology and Stem Cell Research, 2018 Background: Consanguineous marriage is defined as inbreeding between second cousins or closer. In such families there will be a potential increase in the autosomal recessive traits with its lethal effect, with an increased risk of morbidity and mortality
Nidal Karim Al-Rahal
doaj +1 more source
Increased von Willebrand Factor and Defective Ristocetin-Induced platelet Aggregation in Liver Disease [PDF]
, 1977 S Maragall +5 more
openalex +1 more source
Haemophilia Prophylaxis in the Age of Innovation: Exploring Opportunities for Personalized Treatment
Haemophilia, EarlyView.ABSTRACT Introduction Recent advancements in haemophilia treatment have introduced a range of innovative therapies, including activated FVIII mimetics, ultra‐extended half‐life recombinant FVIII, rebalancing agents and gene therapy. These developments have transformed treatment options and expanded prophylaxis strategies.
Yesim Dargaud +5 more
wiley +1 more source
Assessing Mortality of Blunt Trauma with Co-morbidity [PDF]
arXiv, 2017 Objectives: To obtain a better estimate of the mortality of individuals suffering from blunt force trauma, including co-morbidity. Methodology: The Injury severity Score (ISS) is the default world standard for assessing the severity of multiple injuries. ISS is a mathematical fit to empirical field data.
arxiv
Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin. [PDF]
, 1987 Scott D. Berkowitz +7 more
openalex +1 more source
Haemophilia, EarlyView.ABSTRACT Introduction Heavy menstrual bleeding (HMB) is a common presenting symptom in women with bleeding disorders, yet haemostatic testing is sometimes overlooked, even when refractory HMB requires surgical intervention. Aim To determine the prevalence of bleeding disorders in women referred for surgical management of HMB and investigate screening ...
Alison Delaney +8 more
wiley +1 more source
Informative sample generation using class aware generative adversarial networks for classification of chest Xrays [PDF]
arXiv, 2019 Training robust deep learning (DL) systems for disease detection from medical images is challenging due to limited images covering different disease types and severity. The problem is especially acute, where there is a severe class imbalance. We propose an active learning (AL) framework to select most informative samples for training our model using a ...
arxiv
Haemophilia, EarlyView.ABSTRACT Background Von Willebrand disease (vWD) is a common bleeding disorder with different subtypes. Laboratory diagnosis is challenging, involving several expensive and complex assays. The von Willebrand factor (vWF) collagen binding assay (VWF:CB) has been described to improve the diagnosis of vWD, but there is a lack of consensus and its ...
Adrian Kimiaei +7 more
wiley +1 more source