Results 171 to 180 of about 31,578 (263)

Haemophilia A in a Female German Shepherd With Homozygosity for the FVIII p.C567Y Variant in Exon 11 of the F8 Gene

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT Haemophilia A is an extremely rare disorder in females, as the causative F8 gene is located on the X chromosome. Female carriers, also known as ‘conductors,’ are typically heterozygous and therefore do not show clinical signs of the disease. However, in mild forms of haemophilia A, affected males may survive and mate.
Bertram Brenig, Sabrina Pach
wiley   +1 more source

Stratified obstetric management for heterogeneous rare diseases: a precision medicine framework based on four genetic archetypes. [PDF]

Front Med (Lausanne)
Lv S, Yang H, Cui Y, Yang H.
europepmc   +1 more source

A Therapeutic Dilemma: Catastrophic ST‐Elevation Myocardial Infarction Following Antiplatelet Therapy Interruption in a Patient With JAK2‐Positive Polycythemia Vera

Clinical Case Reports, Volume 14, Issue 8, August 2026.
Premature interruption of dual antiplatelet therapy in a patient with polycythemia vera and clinically suspected acquired von Willebrand syndrome triggered catastrophic recurrent stent thrombosis, whereas perioperative bridging with eptifibatide enabled safe surgery. ABSTRACT Polycythemia vera is associated with a thrombotic–hemorrhagic paradox.
Behrouz zarei, Amirhossein Rezaei Latifi, Mohammad Salari   +2 more
wiley   +1 more source

Open‐Label, Balanced, Randomized, Single‐Dose, Three‐Treatment, Three‐Sequence, Three‐Period, Three‐Way Crossover Oral Bioequivalence Study of Desmopressin Acetate Oral Solution

Clinical Pharmacology in Drug Development, Volume 15, Issue 8, August 2026.
ABSTRACT Desmopressin is first‐line therapy for central diabetes insipidus, also known as arginine vasopressin deficiency, but presents dosing challenges due to its narrow therapeutic index. This open‐label, randomized, three‐way crossover study evaluated the bioequivalence of a new desmopressin acetate oral solution (50 mcg/mL) compared to ...
Adam Christensen, Axay Parth, Mansi Kotak, Danka Radosavjevic, Catherine Gorman Moore, Byung‐Woun Seo   +5 more
wiley   +1 more source

A rare case of gastroduodenal junction Kaposiform hemangioendothelioma in a cat: pathological findings and follow-up. [PDF]

Vet Res Commun
Borfălău CD, Negoescu A, Marica R, Hodor D, Bărbulescu A, Radulescu A, Vulcan ET, Gal C, Amorim I, Taulescu M.   +9 more
europepmc   +1 more source

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

von Willebrand disease combined with other hemostasis disorders: an overlooked clinical entity. [PDF]

Res Pract Thromb Haemost
Seidizadeh O, Mannucci PM, Peyvandi F.
europepmc   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source

Heyde syndrome secondary to hypertrophic obstructive cardiomyopathy: a case report. [PDF]

Egypt Heart J
Castellanos-Maldonado A, Canales-Azcona GA, Martínez-Arroyo JL, Maldonado-Valdéz M, Ibarra-Sifuentes HR.   +4 more
europepmc   +1 more source