Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden +3 more
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(Un) Diagnosing von Willebrand disease. [PDF]
Brenner MK, Christopherson PA, Flood VH.
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ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley +1 more source
Structure and multiple functions of von Willebrand factor. [PDF]
Haberichter SL, O'Donnell JS.
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Von Willebrand Factor and ADAMTS13 in Relation to Major Adverse Limb Events in Peripheral Artery Disease. [PDF]
Agid N +5 more
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Preoperative inflammatory profile in chronic coronary syndrome reveals interleukin-2 as a promising biomarker for postoperative atrial fibrillation risk stratification. [PDF]
Cozac DA +6 more
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Clusterin maintains hemostatic equilibrium by stabilizing VWF multimers in plasma.
Qiao Z +11 more
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Clinical Spectrum, Subtype Distribution, and Treatment Outcomes in von Willebrand Disease: A Prospective Study from a Hemophilia Treatment Center in Pakistan. [PDF]
Borhany M +4 more
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Thromboinflammation and hemostatic activation drive early mortality risk in pulmonary embolism. [PDF]
Siddiqui F +7 more
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A Systematic Review and Meta-Analysis on the Effectiveness and Safety of Tranexamic Acid for Postpartum Haemorrhage in Patients with Haemorrhagic Disorders. [PDF]
Adepoju VA +4 more
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