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Bleeding Disorders in Children With Genetic Diseases: A Narrative Review. [PDF]
Acta PaediatrCagol R +6 more
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New England Journal of Medicine, 2016
Von Willebrand's disease is the most common inherited bleeding disorder and is generally transmitted as an autosomal dominant trait. It is mainly associated with mucosal bleeding and excessive bleeding after trauma or surgery. A variety of effective treatments are available.
Leebeek, F.W.G., Eikenboom, J.C.J.
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Von Willebrand's disease is the most common inherited bleeding disorder and is generally transmitted as an autosomal dominant trait. It is mainly associated with mucosal bleeding and excessive bleeding after trauma or surgery. A variety of effective treatments are available.
Leebeek, F.W.G., Eikenboom, J.C.J.
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Pediatric Clinics of North America, 2008
von Willebrand disease is a common inherited bleeding disorder and many cases are diagnosed in childhood. It has a negative impact on the quality of life of affected individuals; therefore, it is important that the condition be recognized and diagnosed.
Jeremy, Robertson +2 more
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von Willebrand disease is a common inherited bleeding disorder and many cases are diagnosed in childhood. It has a negative impact on the quality of life of affected individuals; therefore, it is important that the condition be recognized and diagnosed.
Jeremy, Robertson +2 more
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von Willebrand disease and von Willebrand factor
Haemophilia, 2022AbstractSummaryProgress in both basic and translational research into the molecular mechanisms of VWD can be seen in multiple fields.Genetics of VWDIn the past several decades, knowledge of the underlying pathogenesis of von Willebrand disease (VWD) has increased tremendously, thanks in no small part to detailed genetic mapping of the von Willebrand ...
Brooke, Sadler +2 more
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Human Pathology, 1987
von Willebrand disease (vWD) is a bleeding disorder characterized by a complex hemostatic defect. Abnormal platelet function, usually reflected by a prolonged bleeding time, is the result of a quantitative or qualitative defect of von Willebrand factor (vWF).
T S, Zimmerman, Z M, Ruggeri
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von Willebrand disease (vWD) is a bleeding disorder characterized by a complex hemostatic defect. Abnormal platelet function, usually reflected by a prolonged bleeding time, is the result of a quantitative or qualitative defect of von Willebrand factor (vWF).
T S, Zimmerman, Z M, Ruggeri
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Pediatric Blood & Cancer, 2012
AbstractLong‐term prophylaxis is not as well known in Von Willebrand disease (VWD) as in hemophilia but attempts to evaluate prophylaxis scientifically in VWD have started. A few cohort studies have been reported. In an international effort the Von Willebrand disease prophylaxis network (VWD PN) has been formed to investigate the role of prophylaxis in
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AbstractLong‐term prophylaxis is not as well known in Von Willebrand disease (VWD) as in hemophilia but attempts to evaluate prophylaxis scientifically in VWD have started. A few cohort studies have been reported. In an international effort the Von Willebrand disease prophylaxis network (VWD PN) has been formed to investigate the role of prophylaxis in
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Annual Review of Medicine, 1997
▪ Abstract von Willebrand's disease (vWD) arises from abnormalities in von Willebrand factor (vWF), an adhesive glycoprotein uniquely involved in key aspects of both primary and secondary hemostasis. The current classification distinguishes disorders arising from partial (type 1) or complete (type 3) deficiencies and from qualitative defects (type 2).
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▪ Abstract von Willebrand's disease (vWD) arises from abnormalities in von Willebrand factor (vWF), an adhesive glycoprotein uniquely involved in key aspects of both primary and secondary hemostasis. The current classification distinguishes disorders arising from partial (type 1) or complete (type 3) deficiencies and from qualitative defects (type 2).
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Diagnosis of von Willebrand Disease
Haemophilia, 1999The haemorrhagic diathesis in von Willebrand disease (vWD) is caused by a quantitative deficiency or a qualitative defect in the von Willebrand factor (vWF) in plasma and/or platelets causing insufficient primary haemostasis. Since vWF binds and protects factor VIII (FVIII) towards random proteolysis, coagulation may also be impaired in patients with a
Ingerslev, J, Gursel, T
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Postgraduate Medicine, 1980
Von Willebrand's disease is an autosomally transmitted disorder of hemostasis caused by a deficiency of or defect in the von Willebrand factor in the blood, a protein required for adherence of platelets to an injured vessel wall. The disease's principal manifestations are spontaneous bleeding from mucous membranes, excessive bleeding from wounds, and ...
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Von Willebrand's disease is an autosomally transmitted disorder of hemostasis caused by a deficiency of or defect in the von Willebrand factor in the blood, a protein required for adherence of platelets to an injured vessel wall. The disease's principal manifestations are spontaneous bleeding from mucous membranes, excessive bleeding from wounds, and ...
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von Willebrand Disease and Pregnancy
Journal of Maternal-Fetal and Neonatal Medicine, 2000von Willebrand Disease (vWD) affects approximately 1% of Americans and as many as 25% of women referred for evaluation of menorrhagia. We briefly review the history of vWD, its molecular defects, and diagnostic criteria for each subtype of disease. We also address obstetric management of the patient with vWD. While there is a significant increased risk
H, Roqué, E, Funai, C J, Lockwood
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