Results 161 to 170 of about 58,549 (319)

Diagnostic Performance of Prothrombin Time and Activated Partial Thromboplastin Time in Children: A Service Evaluation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Coagulation screening, consisting of prothrombin time (PT) and activated partial prothrombin time (aPTT), is routinely performed in paediatrics to identify bleeding disorders or guide peri‐procedural management. We evaluated the trends in utilisation and diagnostic yield of PT and aPTT testing as part of coagulation screening in a ...
Gerard Gurumurthy, Mikias Lemma, Lianna Reynolds, John Grainger, Jecko Thachil   +4 more
wiley   +1 more source

Cosegregation of von Willebrand factor gene polymorphisms and possible germinal mosaicism in type IIB von Willebrand disease [PDF]

, 1991
Elizabeth W. Murray, AR Giles, PJ Bridge, IR Peake, D Lillicrap   +4 more
openalex   +1 more source

Proteome‐Guided Drug Target Discovery for Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background and Objective Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease. Materials and Methods We integrated proteomics data from deCODE genetics with periodontitis genome‐wide association studies ...
Zoheir Alayash, Sebastian‐Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Daniel Hagenfeld, Stefan Lars Reckelkamm, Michael Nolde   +8 more
wiley   +1 more source

Molecular studies of von Willebrand disease: reduced von Willebrand factor biosynthesis, storage, and release in endothelial cells derived from patients with type I von Willebrand disease [published erratum appears in Blood 1990 Nov 1;76(9):1901] [PDF]

, 1990
Bruce M. Ewenstein, Aida Inbal, J S Pober, RI Handin   +3 more
openalex   +1 more source

Characterising the Periodontal Granulation Tissue Using scRNAseq

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.
Wentao Zhu, Kathy Fung, Pawan Dhami, Paul Sharpe, Jan Krivanek, Luigi Nibali, Cheng Zhang, Vitor C. M. Neves   +7 more
wiley   +1 more source

Sympathetic innervation of human cervical lymph nodes: A potential neuroimmunomodulatory target for the treatment of T‐cell‐driven autoimmune diseases like MS?

Journal of Anatomy, EarlyView.
Recent animal studies have shown that the sympathetic nervous system (SNS) prevents disease activity of EAE (Experimental autoimmune encephalomyelitis, animal model of Multiple Sclerosis [MS]), presumably through adrenergic activity in the deep cervical lymph nodes (DCLNs).
Christopher Kremer, Claire Mackaaij, Suzanne A. M. W. Verlinde‐Schellekens, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +4 more
wiley   +1 more source

Nomogram for Deep Vein Thrombosis Prediction Post‐Endovascular Thrombectomy in Acute Ischemic Stroke: A Retrospective Multicenter Observational Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Deep vein thrombosis (DVT) is a frequent complication following endovascular thrombectomy (EVT) in patients with acute ischaemic stroke (AIS), potentially leading to fatal pulmonary embolism (PE). Identifying patients early at high risk for DVT is clinically important.
Li Han, Teng‐Wei Pan, Li‐Li Yang, Wei‐Yang Qian, Xiao‐Ping Xu, Feng Wang, Wei‐Zhen Wang, Yang Liu, Wei‐Ying Yang   +8 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Idiopathic immune‐mediated acquired von Willebrand's disease in a patient with angiodysplasia: Demonstration of an unusual inhibitor causing a functional defect and rapid clearance of von Willebrand factor [PDF]

, 1999
Salah Al‐Humood, Dana V. Devine, Laurie Lawson, Stephen H. Nantel, Cedric J. Carter   +4 more
openalex   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source