Results 251 to 260 of about 55,967 (276)

Von Willebrand's disease: clinical management

Haemophilia, 2006
Summary.  The aim of treatment of von Willebrand's disease (VWD) is to correct the dual defect of haemostasis, i.e. the abnormal platelet adhesion due to reduced and/or dysfunctional von Willebrand factor (VWF) and the abnormal coagulation expressed by low levels of factor VIII (FVIII).
A.B. Federici, G. Castaman, A. Thompson, E. Berntorp   +3 more
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Diagnosis of von Willebrand Disease

Haemophilia, 1999
The haemorrhagic diathesis in von Willebrand disease (vWD) is caused by a quantitative deficiency or a qualitative defect in the von Willebrand factor (vWF) in plasma and/or platelets causing insufficient primary haemostasis. Since vWF binds and protects factor VIII (FVIII) towards random proteolysis, coagulation may also be impaired in patients with a
Ingerslev, J, Gursel, T
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Pseudo-von Willebrand's Disease

New England Journal of Medicine, 1982
It is now recognized that von Willebrand's disease, a disorder characterized by a long bleeding time and reduced factor VIII, is a frequent cause of a mild hemorrhagic diathesis.1 Recent studies of...
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Acquired Von Willebrand's Disease

Hematology/Oncology Clinics of North America, 1992
avWD is a rare entity that is primarily associated with lymphoproliferative disorders, most commonly with multiple myeloma, lymphoma, and the myeloproliferative diseases. Various pathogenetic mechanisms have been postulated. The most commonly seen is antibodies directed against the FVIII complex, resulting in either its accelerated destruction or its ...
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Acquired von Willebrand disease

Haemophilia, 1999
Acquired von Willebrand disease (AvWD) is a syndrome that has clinical and laboratory features similar to hereditary vWD. In contrast to the latter it occurs in patients without a family history of previous bleeding tendency.
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Treatment of von Willebrand's disease

Journal of Internal Medicine, 1997
von Willebrand's disease is the most frequent of inherited bleeding disorders (1:100 affected individuals in the general population). The aim of therapy is to correct the dual defects of haemostasis, i.e. abnormal coagulation expressed by low levels of factor VIII and abnormal platelet adhesion expressed by a prolonged bleeding time. There are two main
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Von Willebrand's Disease

Clinics in Haematology, 1983
T S, Zimmerman, Z M, Ruggeri
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Platelet-type von Willebrand’s Disease

Clinics in Laboratory Medicine, 1984
Platelet-type von Willebrand's disease is a recently described disorder of primary hemostasis, possessing attributes both of von Willebrand's disease and of a qualitative platelet abnormality. This article discusses the clinical features, laboratory aspects, pathophysiology, and treatment of platelet-type von Willebrand's disease.
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Erik von Willebrand— von Willebrand's Disease

Mayo Clinic Proceedings, 1996
M A, Shampo, R A, Kyle
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Von Willebrand’s disease

The Indian Journal of Pediatrics, 1993
I M, Nilsson, S, Lethagen
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