Results 231 to 240 of about 147,268 (335)

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Total Thrombus-Formation Analysis System (T-TAS) in Aortopathies: A Conceptual and Potential Framework to Spatial Heterogeneity and Regional Context. [PDF]

Int J Mol Sci
Krych S, Gniewek J, Kolbowicz M, Stępień-Słodkowska M, Adamczyk M, Hrapkowicz T, Kowalczyk P.   +6 more
europepmc   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Promises and Pitfalls of Whole Exome Sequencing in Therapy-Resistant Chronic Thrombocytopenia in Childhood: A Case Report. [PDF]

J Pers Med
Györke E, Benyó G, Árvai KB, Bödör C, Kereskai L, Ábrahám H, Réger B, Egyed B, Ottóffy G.   +8 more
europepmc   +1 more source

Personalized‐Context‐Aware Age Gap: A New Multi‐Omics Measurement Based on Age‐Enhanced Model AOE‐Net for Aging Acceleration and Chronic Disease Risk Prediction

Aging Cell, Volume 25, Issue 6, June 2026.
Addressing systemic biases in traditional aging clocks, we introduce PAAG, a context‐aware multi‐omics metric derived from the pre‐trained AOE‐Net. PAAG accurately captures localized aging acceleration, demonstrating superior predictive power for chronic disease risks and clinical outcomes across diverse aging populations.
Feng‐Ao Wang, Tao Zeng, Chunchun Yuan, Hongyu Wang, Yule Yu, Enjin Deng, Yao Wang, Jiangxun Ji, Jiarui Cui, Dezhi Tang, Ruikun He, Yongjun Wang, Yixue Li   +12 more
wiley   +1 more source

von Willebrand disease combined with other hemostasis disorders: an overlooked clinical entity. [PDF]

Res Pract Thromb Haemost
Seidizadeh O, Mannucci PM, Peyvandi F.
europepmc   +1 more source

Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases. [PDF]

Proc Natl Acad Sci U S A, 2015
Kim J, Hudson NE, Springer TA.
europepmc   +1 more source

Crohn's Disease Complicated by Undiagnosed Hemophilia A: A Case of Recurrent Massive Lower Gastrointestinal Bleeding. [PDF]

ACG Case Rep J
Soares C, Rodrigues M, Martins D, Sousa P, Cancela E, Ferreira MJ, Casimiro C, Silva A, Ministro P.   +8 more
europepmc   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

(Un) Diagnosing von Willebrand disease. [PDF]

Hematology Am Soc Hematol Educ Program
Brenner MK, Christopherson PA, Flood VH.
europepmc   +1 more source