Results 261 to 270 of about 102,475 (311)

Von Willebrand factor and thrombosis

Annals of Hematology, 2006
There is increasing evidence that von Willebrand factor (VWF), an adhesive multimeric protein that has an important function in primary hemostasis and as a carrier of factor VIII, has a pivotal role in thrombogenesis. In fact, while the presence in plasma of unusually large VWF multimers due to a congenital or acquired deficiency of a VWF-cleaving ...
Franchini M, LIPPI, Giuseppe
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Platelet von Willebrand factor: Comparison with plasma von Willebrand factor

Thrombosis Research, 1985
Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that the multimeric organization was different, larger multimers were present, and the ratio of vWf activity to antigen was higher.
H R, Gralnick, S B, Williams, L P, McKeown, D M, Krizek, B C, Shafer, M E, Rick   +5 more
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Antibodies to von Willebrand factor in von Willebrand disease

1995
The occurrence of an alloantibody directed against von Willebrand factor in a multitransfused patient with severe (type III) von Willebrand disease was first reported in 2 consecutive studies by Sarji et al. (1974) and Stratton et al. (1975). After this, 14 additional cases of alloantibodies were described and reviewed by Mannucci and Mari (1984).
P.M. Mannucci, A.B. Federici
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Von Willebrand Factor and the Endothelium

Mayo Clinic Proceedings, 1991
Endothelial cells are the principal source of plasma and basement membrane von Willebrand factor (vWF). To arrive at its biologically active multimeric form, vWF undergoes a series of intracellular processing steps. The protein is synthesized as a large precursor pro-vWF, which dimerizes in the endoplasmic reticulum through disulfide bonds located in ...
D D, Wagner, R, Bonfanti
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Platelets and von Willebrand factor

Transfusion and Apheresis Science, 2003
The interaction of platelets with von Willebrand factor (VWF) is crucial in the initiation of any hemostatic or thrombotic process. VWF enables the platelet, via its surface glycoprotein receptors, to adhere to exposed subendothelium and to respond to shear stress in the blood.
Markus, Schmugge, Margaret L, Rand, John, Freedman   +2 more
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von Willebrand factor to the rescue

Blood, 2009
Abstractvon Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of bleeding complications, known as von Willebrand disease (VWD), the most common inherited bleeding disorder in humans.
Simon F, De Meyer, Hans, Deckmyn, Karen, Vanhoorelbeke   +2 more
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Platelet von Willebrand Factor

Mayo Clinic Proceedings, 1991
von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is synthesized and released from endothelial cells; the second, synthesized by megakaryocytes, circulates in platelets primarily stored in the alpha granules.
H R, Gralnick, S B, Williams, L P, McKeown, L, Magruder, K, Hansmann, M, Vail, R I, Parker   +6 more
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von Willebrand's factor and von Willebrand's disease.

Current opinion in hematology, 1997
von Willebrand's factor is required for platelet adhesion to subendothelium, and for normal factor VIII survival in the circulation. These functions require the assembly of von Willebrand's factor into multimers that exhibit properly regulated binding to platelet glycoprotein lb. Recent studies suggest that the propeptide of von Willebrand's factor may
T, Matsushita, Z, Dong, J E, Sadler
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[Von Willebrand factor and Von Willebrand disease].

Nederlands tijdschrift voor geneeskunde, 2014
Von Willebrand factor (VWF) is a multimeric adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in the circulation. VWD is classified into three major subtypes, distinguished by a quantitative deficiency of VWF (type 1: partial deficiency; type 3: complete deficiency) or qualitative defects of VWF (type 2A, 2B, 2M ...
Paul W M, Verhezen, Erik A M, Beckers, Yvonne M C, Henskens   +2 more
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von Willebrand factor and von Willebrand disease.

Blood, 1987
Progress has occurred in the past several years in the understanding of the structure and function of von Willebrand factor (vWF). This multimeric glycoprotein exhibits a dual role, that of mediating platelet adhesion and aggregation onto thrombogenic surfaces, and that of functioning as carrier in plasma for the factor VIII procoagulant protein.
Z M, Ruggeri, T S, Zimmerman
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