Results 61 to 70 of about 52,334 (267)
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
The epitope of the antibody used in the REAADS VWF activity assay is quaternary
Thrombosis JournalThe REAADS VWF activity assay is often assumed to be specific for the A1 domain, the portion of VWF that binds platelet GPIbα. We tested this assay on the A1A2A3 region of VWF with each domain expressed independently of one another and together in ...
Alexander Tischer +2 more
doaj +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
von Willebrand Factor (VWF) Inhibitors in Two Brothers with von Willebrand Disease: A Case Report
TH OpenThe development of inhibitors to von Willebrand factor (VWF) is a rare but potentially serious complication of VWF replacement therapy in patients with von Willebrand disease (VWD).
Claudia Djambas Khayat +4 more
doaj +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2020 Aim : Type 3 von Willebrand disease (VWD) is the most severe form of VWD, characterized by a near-total absence of von Willebrand factor (vWF) leading to a huge deficiency in plasmatic factor VIII (FVIII). VWD may be confused with hemophilia A, sometimes
Adia Eusèbe Adjambri +7 more
doaj +1 more source
Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source
Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets [PDF]
Blood, 1982 A form of von Willebrand's disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIII/von Willebrand factor protein (type IIb). We studied two families with this form of von Willebrand's disease and macrothrombocytopenia.
H R, Gralnick +3 more
openaire +3 more sources
Ecography, EarlyView.Ecosystem dynamics are shaped by interacting top‐down and bottom‐up processes, yet their relative importance may vary through time following disturbances such as disease outbreaks and changes in apex predator communities. Using a 52‐year time series in south‐central Sweden, we examined how disease, apex predators, and prey availability jointly impact a
Camilla Wikenros +4 more
wiley +1 more source
Septal Release: A Targeted Surgical Strategy for Recurrent Epistaxis
Eye &ENT Research, EarlyView.ABSTRACT Background Recurrent epistaxis is a common pediatric condition that is typically managed with conservative therapies, but a subset of patients require surgical intervention after treatment failure. We seek to describe the efficacy of septal release for refractory pediatric epistaxis patients. Objective To compare outcomes of septal release for
Alexandra Welschmeyer +6 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source