Results 41 to 50 of about 601,506 (352)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Detecting androgen receptor (AR), AR variant 7 (AR-V7), prostate-specific membrane antigen (PSMA), and prostate-specific antigen (PSA) gene expression in CTCs and plasma exosome-derived cfRNA in patients with metastatic castration-resistant prostate cancer (mCRPC) by integrating the VTX-1 CTC isolation system with the QIAGEN AdnaTest

BMC Cancer
Background Therapies for metastatic castration-resistant prostate cancer (mCRPC) include targeting the androgen receptor (AR) with androgen receptor inhibitors (ARIs) and prostate-specific membrane antigen (PSMA).
Haiyan E. Liu, Meghah Vuppalapaty, Christian R. Hoerner, Colin P. Bergstrom, Michael Chiu, Clementine Lemaire, James Che, Amanpreet Kaur, Adam Dimmick, Sean Liu, Thomas J. Metzner, Menna Araya, Steve Crouse, Markus Sprenger-Haussels, Martin Schlumpberger, John T. Leppert, Siegfried Hauch, Elodie Sollier, Alice C. Fan   +18 more
doaj   +1 more source

Topological Aspect of Knotted Vortex Filaments in Excitable Media

, 2007
Scroll waves exist ubiquitously in three-dimensional excitable media. It's rotation center can be regarded as a topological object called vortex filament.
, Calini A, Duan Yi-Shi, Goursat E, Pohl W, Ren J R, Ren Ji-Rong, Rolfsen D, Schouten J A, Wu N J, Zhang H, Zhang H, Zhu Tao   +12 more
core   +1 more source

Analysis of model rotor blade pressures during parallel interaction with twin vortices [PDF]

, 2005
This paper presents and provides analysis of unsteady surface pressures measured on a model rotor blade as the blade experienced near parallel blade vortex interaction with a twin vortex system.
Beddoes T. S., Brocklehurst A., Caradonna F. X., Caradonna F. X., Copland C. M., Coton F. N., F. N. Coton, Gowanlock D. K., Hoad D. R., Horner M. B., Jones H. E., Liu Z., Lowson M. V., Masson C. A., Padakannaya R., R. A. McD. Galbraith, R. B. Green, Tangler J. L., Tyler D. J., Wu J. M.   +19 more
core   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

On a Multifractal Approach of Turbulent Atmosphere Dynamics

Frontiers in Earth Science, 2020
This paper aims to present a multifractal approach of the turbulent atmosphere, by proposing that it can be considered a complex system whose structural units support dynamics on continuous but non-differentiable multifractal curves.
Iulian Alin Roşu, Marius Mihai Cazacu, Adrian Stelian Ghenadi, Luminita Bibire, Maricel Agop, Maricel Agop   +5 more
doaj   +1 more source

Investigation on Flow Characteristics of Swept Shock/Turbulent Boundary Layer Interaction Considering Entropy Layer Effect

气体物理, 2023
In order to explore the effect of entropy layer on swept shock/turbulent boundary layer interaction, numerical simulation was applied to study a fin/blunt plate physical model.
Xian-kai LI, Fa-jia SHENG, Jia-wei LI, Chao YIN, Mo-fan HE, Hang ZHOU, Jun LIU   +6 more
doaj   +1 more source

Vulcanized vortex

Physical Review D, 2009
9 pages, 5 figures, final version published in Physical Review ...
Youngone Lee, Inyong Cho
openaire   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Serious game for cognitive assessment. Validation of a psychometric embedded test

International Journal of Serious Games
The evaluation of performance in serious video games is crucial when it comes to providing empirical evidence of the effectiveness of this type of educational tools.
Jorge Quimbaya, Alejandra Herrera, Cesar Mejia   +2 more
doaj   +1 more source