Results 41 to 50 of about 186,990 (299)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Vortical Structure and Aerodynamics of Hawkmoth Hovering
Journal of Biomechanical Science and Engineering, 2006 A multi-block-and overset grid-based computational fluid dynamic (CFD) study is conducted for the unsteady flows about a realistic body-wing model and the force-generation in the flapping flight of hawkmoth hovering.
Hikaru AONO, Hao LIU
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Three-dimensional vortex structure in a wake of a free-flight butterfly
Nihon Kikai Gakkai ronbunshu, 2016 A number of studies on not only the mechanism of insect flight but also the flow field around insect wings have been performed. Especially, a number of recent studies have examined the flow field around insect wings using experimental and numerical ...
Masaki FUCHIWAKI, Kazuhiro TANAKA
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Applied SciencesThis study investigates the application of soft magnetic composite (SMC) materials in alternator core manufacturing for bladeless wind turbines operating under the principle of vortex-induced vibration (VIV), employing additive manufacturing (AM ...
Enrique González-González +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Publications of the Research Institute for Mathematical Sciences, 2004 We discuss how the geometry of _D_2-_D_0 branes may be related to Gromov–Witten theory of Calabi–Yau threefolds.
openaire +4 more sources
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source