Results 61 to 70 of about 538,069 (301)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

3D-Printed SMC Core Alternators: Enhancing the Efficiency of Vortex-Induced Vibration (VIV) Bladeless Wind Turbines

Applied Sciences
This study investigates the application of soft magnetic composite (SMC) materials in alternator core manufacturing for bladeless wind turbines operating under the principle of vortex-induced vibration (VIV), employing additive manufacturing (AM ...
Enrique González-González, David J. Yáñez, Arturo Hidalgo, Susana Del Pozo, Susana Lagüela   +4 more
doaj   +1 more source

Effect of the Preheating Strategy on the Combustion Process of the Intake Manifold Burner

Applied Sciences, 2022
The intake air preheating is an effective method to improve the cold start performance of diesel engines. The combustion process and ignition probability were investigated in the present study.
Zhishuang Li, Ziman Wang, Haoyang Mo
doaj   +1 more source

(Giant) Vortex - (anti) vortex interaction in bulk superconductors: The Ginzburg-Landau theory

, 2010
The vortex-vortex interaction potential in bulk superconductors is calculated within the Ginzburg-Landau (GL) theory and is obtained from a numerical solution of a set of two coupled non-linear GL differential equations for the vector potential and the ...
Andrey Chaves, D. R. Tilley, E. B. Bogomol’nyi, F. M. Peeters, G. A. Farias, M. V. Milošević, William H. Press   +6 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Causes and Consequences of Ordering and Dynamic Phases of Confined Vortex Rows in Superconducting Nanostripes

Nanomaterials, 2022
Understanding the behaviour of vortices under nanoscale confinement in superconducting circuits is important for the development of superconducting electronics and quantum technologies.
Benjamin McNaughton, Nicola Pinto, Andrea Perali, Milorad V. Milošević   +3 more
doaj   +1 more source

Stable and Metastable vortex states and the first order transition across the peak effect region in weakly pinned 2H-NbSe_2 [PDF]

, 2000
The peak effect in weakly pinned superconductors is accompanied by metastable vortex states. Each metastable vortex configuration is characterized by a different critical current density J_c, which mainly depends on the past thermomagnetic history of the
A. I. Larkin, A. I. Larkin, A. I. Larkin, A. K. Grover, C. P. Bean, C. P. Bean, D. J. Bishop, E. Bucher, E. Zeldov, G. Ravikumar, G. Ravikumar, G. Ravikumar, G. Ravikumar, G. Ravikumar, G. Ravikumar, G. Ravikumar, H. Pastoriza, K. Tenya, M. J. Higgins, M. J. Higgins, M. Steingart, P. Chaddah, P. L. Gammel, P. L. Gammel, R. Wordenweber, S. B. Roy, S. B. Roy, S. Bhattacharya, S. Kokkaliaris, S. Ramakrishnan, S. S. Banerjee, S. S. Banerjee, S. Sarkar, T. Giamarchi, T. Giamarchi, T. Giamarchi, T. V. Chandrasekhar Rao, U. Welp, V. C. Sahni, W. A. Fietz, W. Henderson, W. Henderson, Y. Paltiel   +42 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Vortex lattices of layered HTSCs at different vortex–vortex interaction potentials

Beilstein Journal of Nanotechnology
Magnetization reversal processes in a vortex system with different potentials of vortex–vortex interaction were studied using the Monte Carlo method within the framework of a two-dimensional model of a layered high-temperature superconductor. Interaction potentials close to the potential applicable in superconductors with the Ginzburg–Landau parameter ...
Valerii P Lenkov, Anastasia N Maksimova, Anna N Moroz, Vladimir A Kashurnikov   +3 more
openaire   +3 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source