Results 41 to 50 of about 219,945 (319)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Energies, 2021 The testing of the standard and modified SST models of the transfer of shear stresses was carried out on an example of calculating the heat transfer with an intense detached flow around a conical dimple with a slope angle of 45° on the heated wall of a ...
Sergey Isaev +7 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Serious game for cognitive assessment. Validation of a psychometric embedded test
International Journal of Serious GamesThe evaluation of performance in serious video games is crucial when it comes to providing empirical evidence of the effectiveness of this type of educational tools.
Jorge Quimbaya +2 more
doaj +1 more source
, 1998 In this paper we present new results concerning the evolution and stability of vortex knots in the context of the Euler equations. For the first time, since Lord Kelvin’s original conjecture of 1875, we have direct numerical evidence of stability of vortex filaments in the shape of torus knots. The results are based on the analytical solutions of Ricca
Barenghi, CF, Ricca, R, Samuels, DC
openaire +2 more sources
Intake Ground Vortex Aerodynamics [PDF]
, 2008 When an aircraft is operating in static or near static conditions during taxiing or take-o a vortex can form between the ground and the intake. With engine diameters increasing, intakes are moving non-dimensionally closer to the ground and as a ...
Murphy, John
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Research on the Unsteady Flow and Vortex Characteristics of Cavitation at the Tongue in Centrifugal Pump [PDF]
Journal of Applied Fluid MechanicsIn order to study the unsteady flow and vortex characteristics of tongue cavitation, numerical calculation is carried out for the whole flow channel given different conditions. Then, the calculation results are verified experimentally.
Z. Y. Luo +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Wake structure and kinematics in the vortex ring state
, 2009 High-resolution computational simulations of the vortical wake of a rotor operating both near to and within the vortex ring state have been conducted using Brown's vorticity transport model.
Brown, R.E., Ahlin, G.A.
core +1 more source