Results 41 to 50 of about 538,069 (301)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Detecting androgen receptor (AR), AR variant 7 (AR-V7), prostate-specific membrane antigen (PSMA), and prostate-specific antigen (PSA) gene expression in CTCs and plasma exosome-derived cfRNA in patients with metastatic castration-resistant prostate cancer (mCRPC) by integrating the VTX-1 CTC isolation system with the QIAGEN AdnaTest

BMC Cancer
Background Therapies for metastatic castration-resistant prostate cancer (mCRPC) include targeting the androgen receptor (AR) with androgen receptor inhibitors (ARIs) and prostate-specific membrane antigen (PSMA).
Haiyan E. Liu, Meghah Vuppalapaty, Christian R. Hoerner, Colin P. Bergstrom, Michael Chiu, Clementine Lemaire, James Che, Amanpreet Kaur, Adam Dimmick, Sean Liu, Thomas J. Metzner, Menna Araya, Steve Crouse, Markus Sprenger-Haussels, Martin Schlumpberger, John T. Leppert, Siegfried Hauch, Elodie Sollier, Alice C. Fan   +18 more
doaj   +1 more source

Generation of Circularly Polarized Quasi-Non-Diffractive Vortex Wave via a Microwave Holographic Metasurface Integrated with a Monopole

Applied Sciences, 2021
In this paper, a novel method for generating a circularly polarized (CP) quasi-non-diffractive vortex wave carrying orbital angular momentum (OAM), based on the microwave holographic metasurface integrated with a monopole, is proposed. This method is the
Chen Zhang, Li Deng, Ling Wang, Xue Chen, Shufang Li   +4 more
doaj   +1 more source

Equilibrium rotation of a vortex bundle terminating on a lateral wall

, 2011
The paper investigates possibility of equilibrium solid-body rotation of a vortex bundle diverging at some height from a cylinder axis and terminating on a lateral wall of a container.
E. B. Sonin, E. B. Sonin, I. M. Khalatnikov, L. D. Landau, R. Donnelly, S. K. Nemirovskii, T. Sh. Misirpashaev, T. Sh. Misirpashaev   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Vortex Surface in a Three-Body Quantum System

Atoms, 2023
Vortices are structures known in our daily lives and observed in a wide variety of systems, from cosmic to microscopic scales. Relatively recent studies showed that vortices could also appear in simple quantum systems.
Tamara A. Guarda, Francisco Navarrete, Raúl O. Barrachina   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Serious game for cognitive assessment. Validation of a psychometric embedded test

International Journal of Serious Games
The evaluation of performance in serious video games is crucial when it comes to providing empirical evidence of the effectiveness of this type of educational tools.
Jorge Quimbaya, Alejandra Herrera, Cesar Mejia   +2 more
doaj   +1 more source

Standard and Modified SST Models with the Consideration of the Streamline Curvature for Separated Flow Calculation in a Narrow Channel with a Conical Dimple on the Heated Wall

Energies, 2021
The testing of the standard and modified SST models of the transfer of shear stresses was carried out on an example of calculating the heat transfer with an intense detached flow around a conical dimple with a slope angle of 45° on the heated wall of a ...
Sergey Isaev, Dmitry Nikushchenko, Alexandr Sudakov, Nikita Tryaskin, Ann Egorova, Leonid Iunakov, Alexandr Usachov, Valery Kharchenko   +7 more
doaj   +1 more source

Dynamics of Vortex Core Switching in Ferromagnetic Nanodisks

, 2006
Dynamics of magnetic vortex core switching in nanometer-scale permalloy disk, having a single vortex ground state, was investigated by micromagnetic modeling.
Choi, B. C., Donohoe, G., Hong, Y. K., Rudge, J., Xiao, Q. F.   +4 more
core   +1 more source