Results 51 to 60 of about 111,541 (269)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mirror-Symmetry-Breaking in Poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-biphenyl] (PF8P2) is Susceptible to Terpene Chirality, Achiral Solvents, and Mechanical Stirring

Molecules, 2013
Solvent chirality transfer of (S)-/(R)-limonenes allows the instant generation of optically active PF8P2 aggregates with distinct circular dichroism (CD)/circularly polarized luminescence (CPL) amplitudes with a high quantum yield of 16–20%.
Ayako Nakao, Yoshifumi Kawagoe, Yoko Nakano, Michiya Fujiki   +3 more
doaj   +1 more source

Applicability of Dynamic Inflow Models of HAWT in Yawed Flow Conditions

Energies, 2022
Horizontal axis wind turbines (HAWTs) experience yaw misalignments due to the physical limitations of yaw controllers and various novel active yaw controls. Moreover, the motion of floating offshore wind turbines (FOWTs) accelerates yaw misalignment. The
Chihoon Hur, Carlos Ferreira, Gerard Schepers   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Theoretical and Numerical Study on Buongiorno’s Model with a Couette Flow of a Nanofluid in a Channel with an Embedded Cavity

Applied Sciences, 2022
In the present paper, the fluid flow and heat transfer of a nanofluid are numerically investigated. More specifically, reference is made to a nanofluid, described by means of Buongiorno’s model, subjected to Couette flow.
Eugenia Rossi di Schio, Andrea Natale Impiombato, Abderrahim Mokhefi, Cesare Biserni   +3 more
doaj   +1 more source

Vortex lattices of layered HTSCs at different vortex–vortex interaction potentials

Beilstein Journal of Nanotechnology
Magnetization reversal processes in a vortex system with different potentials of vortex–vortex interaction were studied using the Monte Carlo method within the framework of a two-dimensional model of a layered high-temperature superconductor. Interaction potentials close to the potential applicable in superconductors with the Ginzburg–Landau parameter ...
Valerii P Lenkov, Anastasia N Maksimova, Anna N Moroz, Vladimir A Kashurnikov   +3 more
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Hydrodynamic Performance and Vortex Structure Analysis of a Toroidal Propeller

Journal of Marine Science and Engineering
Because of their distinctive toroidal blade configuration, toroidal propellers can improve propulsion efficiency, reduce underwater noise, and enhance blade stability and strength.
Jie Bai, Yunhai Li, Xiaohui Liu, Hongliang Zhang, Liuzhen Ren   +4 more
doaj   +1 more source

Reduction effects of drag by a wind deflector attached on a truck container

Nihon Kikai Gakkai ronbunshu, 2014
Recently, reduction of CO2 emissions from automobiles is carried out in the world. The improvement in aerodynamics and reduced in CO2 emissions have been realized with passenger cars.
Satoshi HOKIMOTO, Yoshihiro KOBAYASHI, Hideharu KOYAMA, Yasushi TAKAHASHI   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source