Results 51 to 60 of about 219,945 (319)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of the Preheating Strategy on the Combustion Process of the Intake Manifold Burner

Applied Sciences, 2022
The intake air preheating is an effective method to improve the cold start performance of diesel engines. The combustion process and ignition probability were investigated in the present study.
Zhishuang Li, Ziman Wang, Haoyang Mo
doaj   +1 more source

Geometry and dynamics of vortex sheets in 3 dimensions [PDF]

, 2002
We consider the properties and dynamics of vortex sheets from a geometrical, coordinate-free, perspective. Distribution-valued forms (de Rham currents) are used to represent the fluid velocity and vorticity due to the vortex sheets. The smooth velocities
Burton D.A., Burton, David A, D.A. Burton, R.W. Tucker, Tucker R.W., Tucker, Robin   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

3D-Printed SMC Core Alternators: Enhancing the Efficiency of Vortex-Induced Vibration (VIV) Bladeless Wind Turbines

Applied Sciences
This study investigates the application of soft magnetic composite (SMC) materials in alternator core manufacturing for bladeless wind turbines operating under the principle of vortex-induced vibration (VIV), employing additive manufacturing (AM ...
Enrique González-González, David J. Yáñez, Arturo Hidalgo, Susana Del Pozo, Susana Lagüela   +4 more
doaj   +1 more source

Causes and Consequences of Ordering and Dynamic Phases of Confined Vortex Rows in Superconducting Nanostripes

Nanomaterials, 2022
Understanding the behaviour of vortices under nanoscale confinement in superconducting circuits is important for the development of superconducting electronics and quantum technologies.
Benjamin McNaughton, Nicola Pinto, Andrea Perali, Milorad V. Milošević   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Aircraft Wake-Vortex Evolution in Ground Proximity: Analysis and Parameterization

, 2006
Field measurement data of 282 wake vortex pairs and respective environmental conditions acquired at Frankfurt Airport by means of lidar, Sodar/RASS, and ultrasonic anemometer are used to analyze wake vortex behavior in ground proximity. Exceptional cases
Steen, Meiko, Frank Holzäpfel, Meiko Steen, Holzäpfel, Frank   +3 more
core   +1 more source

Chemical observations of a polar vortex intrusion [PDF]

, 2006
An intrusion of vortex edge air into the interior of the Arctic polar vortex was observed on the 31 January 2005 flight of the NASA DC-8 aircraft. This intrusion was identified as anomalously high values of ozone by Airborne Raman Ozone, Temperature, and
Lait, L. R., Livesey, N., Waters, J., Kawa, S. R., Browell, E. V., Twigg, L., Douglass, A. R., Read, W., McGee, T. J., Froidevaux, L., Santee, M. L., Schoeberl, M. R., Pumphrey, H. C.   +12 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source