Results 31 to 40 of about 1,683 (266)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
EPJ Web of Conferences, 2012 This paper focuses on a suppression of the flow separation, which occurs on a deflected flap, by means of vortex generators (VG's). An airfoil NACA 63A421 with a simple flap and vane-type vortex generators were used.
Matějka Milan +3 more
doaj +1 more source
Energies, 2022 Vortex generators are used to overturn the momentum of the flow in the boundary layer, thereby preventing flow separation, and are broadly used in aviation, wind power, heat exchange, and different fields. It has been determined that the capability of an
Zhaohuang Zhang, Weiwei Li
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A generalization of vortex lines [PDF]
Journal of Geometry and Physics, 2018 8 pages, 3 figures; version to be published in Journal of Geometry and ...
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Air-Side Heat Transfer Enhancement Using Vortex Generators on Heat Transfer Surfaces- A Comprehensive Review [PDF]
Journal of Heat and Mass Transfer ResearchThe main purpose of this article is to provide a critical analysis of published research on these heat transfer surfaces. Important experimental methods and numerical procedures are explained, and many types of vortex generators are described.
Vaibhav Harishchandra Bansode +8 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Control of Laminar Separation Bubble using Vortex Generators
Journal of Applied Fluid Mechanics, 2019 In this paper, the performance of sub boundary layer vortex generators and conventional vortex generators in controlling the separation bubble has been compared and the resultant highly three-dimensional flow has been studied.
N. K. Singh
doaj