Results 61 to 70 of about 22,955 (198)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Brain volumetry by voxel-based-morphometry in migraineurs: comparison between groups and clinical correlations

Headache Medicine, 2022
Background Migraine was previously interpreted as “benign” disease since the major part of patients were asymptomatic between attacks and brain lesions are absent in primary headaches.
Natália de Oliveira Silva, Nicoly Machado Maciel, Gabriela Ferreira Carvalho, Débora Bevilaqua-Grossi, Antônio Carlos dos Santos, Fabíola Dach   +5 more
doaj   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Objective Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer’s disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD ...
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Tissue Clearing for Lymph Nodes: 3D Mapping of Nerves and the Immune Microenvironment

iNew Medicine, EarlyView.
ABSTRACT Lymph nodes (LNs) are central hubs of adaptive immunity and key relay sites for metastatic tumour cells. However, conventional two‐dimensional histology samples only a small fraction of each node, potentially missing micrometastases and multifocal involvement while obscuring long‐range spatial relationships among tumour deposits, immune ...
Guang‐Hong Su, Fei Wang, Ting‐Hong Wei, Rui Lu, Wen‐Jun Huang, Xiang Zhang, Ling Yin, Jun Li   +7 more
wiley   +1 more source

The Combination of DAT-SPECT, Structural and Diffusion MRI Predicts Clinical Progression in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2019
There is an increasing interest in identifying non-invasive biomarkers of disease severity and prognosis in idiopathic Parkinson’s disease (PD). Dopamine-transporter SPECT (DAT-SPECT), diffusion tensor imaging (DTI), and structural magnetic resonance ...
Sara Lorio, Sara Lorio, Sara Lorio, Fabio Sambataro, Fabio Sambataro, Alessandro Bertolino, Alessandro Bertolino, Bogdan Draganski, Bogdan Draganski, Juergen Dukart, Juergen Dukart, Juergen Dukart   +11 more
doaj   +1 more source

A voxel based morphometry study on mild cognitive impairment [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2005
Mild cognitive impairment (MCI) is the most widely used concept in classifying cognitive impairment in the elderly who do not fulfil the criteria for dementia. MCI is considered to confer an increased risk of progressing to dementia and most often Alzheimer's disease (AD). Various approaches such as imaging of the brain have been applied to predict the
C, Pennanen, C, Testa, M P, Laakso, M, Hallikainen, E-L, Helkala, T, Hänninen, M, Kivipelto, M, Könönen, A, Nissinen, S, Tervo, M, Vanhanen, R, Vanninen, G B, Frisoni, H, Soininen   +13 more
openaire   +2 more sources

Influence of Group on Individual Subject Maps in SPM Voxel Based Morphometry

Frontiers in Neuroscience, 2016
Voxel based morphometry (VBM) is a widely utilized neuroimaging technique for spatially normalizing brain structural MRI (sMRI) onto a common template.
Andrew M. Michael, Andrew M. Michael, Eli Evans, Gregory J. Moore, Gregory J. Moore   +4 more
doaj   +1 more source

Optimized voxel-based morphometry in children with developmental dyscalculia [PDF]

NeuroImage, 2008
Developmental dyscalculia (DD) is a specific learning disability affecting the normal acquisition of arithmetic skills. Current studies estimate that 3-6% of the school population is affected by DD. Genetic, neurobiological, and epidemiologic evidence indicates that dyscalculia is a brain-based disorder.
Stephanie Rotzer, Karin Kucian, Ernst Martin, Michael von Aster, Peter Klaver, Thomas Loenneker   +5 more
openaire   +4 more sources

Decoding the Gut‐Brain Axis: Multi‐Omics Reveals a Causal Chain Linking Human Genome, Gut Microbiota, Blood Metabolites, and Alertness in the Brain

Med Research, EarlyView.
This multi‐omics study identified genetic loci, gut microbiota, blood metabolites, and gray matter volumes of orbitofrontal cortex and cerebellum that were potentially relevant to alerting in healthy Chinese adults. Subsequent two‐step one‐sample Mendelian randomization further revealed a serial mediation pathway: Bacteroides intestinalis influences ...
Hongru Li, Chuansheng Chen, Ofir Turel, Yu Pu, Hong Chen, Tingyong Feng, Jiang Qiu, Xu Lei, Qinghua He   +8 more
wiley   +1 more source

Voxel‐based dysconnectomic brain morphometry with computed tomography in Down syndrome

Annals of Clinical and Translational Neurology
Objective Alzheimer's disease (AD) is a major health concern for aging adults with Down syndrome (DS), but conventional diagnostic techniques are less reliable in those with severe baseline disability.
Beatriz Sánchez‐Moreno, Linda Zhang, Gloria Mateo, Fernando Moldenhauer, Mikael Brudfors, John Ashburner, Parashkev Nachev, Diego Real deAsúa, Bryan A. Strange   +8 more
doaj   +1 more source