Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology [PDF]
Virology Journal, 2006 Recently we described a role for Ebola virus proteins, NP, GP, and VP35 in enhancement of VP40 VLP budding. To explore the possibility that VLP structure was altered by co-expression of EBOV proteins leading to the observed enhancement of VP40 VLP ...
Harty Ronald N +2 more
doaj +7 more sources
A Loop Region in the N-Terminal Domain of Ebola Virus VP40 Is Important in Viral Assembly, Budding, and Egress [PDF]
Viruses, 2014 Ebola virus (EBOV) causes viral hemorrhagic fever in humans and can have clinical fatality rates of ~60%. The EBOV genome consists of negative sense RNA that encodes seven proteins including viral protein 40 (VP40).
Emmanuel Adu-Gyamfi +5 more
doaj +5 more sources
Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form [PDF]
Cell Reports, 2021 Summary: The Ebola virus matrix protein VP40 forms distinct structures linked to distinct functions in the virus life cycle. Dimeric VP40 is a structural protein associated with virus assembly, while octameric, ring-shaped VP40 is associated with ...
Sara Landeras-Bueno +8 more
doaj +2 more sources
Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs [PDF]
Viruses, 2021 Filoviruses Ebola (EBOV) and Marburg (MARV) are devastating high-priority pathogens capable of causing explosive outbreaks with high human mortality rates.
Ariel Shepley-McTaggart +7 more
doaj +2 more sources
PLoS ONE, 2012 The matrix protein VP40 coordinates numerous functions in the viral life cycle of the Ebola virus. These range from the regulation of viral transcription to morphogenesis, packaging and budding of mature virions.
Leslie P Silva +4 more
doaj +3 more sources
Impact of Ebola virus nucleoprotein on VP40 virus-like particle production: a computational approach [PDF]
Communications BiologyEbola virus (EBOV) matrix protein VP40 can assemble and bud as virus-like particles (VLPs) when expressed alone in mammalian cells. Nucleoprotein (NP) could be recruited to VLPs as inclusion body (IB) when co-expressed, and increase VLP production ...
Xiao Liu +2 more
doaj +2 more sources
PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding [PDF]
Journal of Lipid ResearchEbola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in ...
Kristen A. Johnson +8 more
doaj +2 more sources
Packaging of actin into Ebola virus VLPs [PDF]
Virology Journal, 2005 The actin cytoskeleton has been implicated in playing an important role assembly and budding of several RNA virus families including retroviruses and paramyxoviruses.
Harty Ronald N, Han Ziying
doaj +4 more sources
Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40 [PDF]
, 2015 Marburg virus (MARV), which belongs to the virus family Filoviridae, causes hemorrhagic fever in humans and nonhuman primates that is often fatal. MARV is a lipid-enveloped virus that during the replication process extracts its lipid coat from the plasma
Stahelin, Robert V. +1 more
core +3 more sources
Microbiology SpectrumEbola virus (EBOV) infection is threatening human health, especially in Central and West Africa. Limited clinical trials and the requirement of biosafety level-4 laboratories hinder experimental work to advance our understanding of EBOV and the ...
Xiao Liu +3 more
doaj +2 more sources