Results 91 to 100 of about 2,213 (186)

Identification of continuous human B-cell epitopes in the VP35, VP40, nucleoprotein and glycoprotein of Ebola virus. [PDF]

PLoS ONE, 2014
Ebola virus (EBOV) is a highly virulent human pathogen. Recovery of infected patients is associated with efficient EBOV-specific immunoglobulin G (IgG) responses, whereas fatal outcome is associated with defective humoral immunity.
Pierre Becquart, Tanel Mahlakõiv, Dieudonné Nkoghe, Eric M Leroy   +3 more
doaj   +1 more source

Computational and experimental identification of keystone interactions in Ebola virus matrix protein VP40 dimer formation

Protein Science, Volume 33, Issue 5, May 2024.
Abstract The Ebola virus (EBOV) is a lipid‐enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV is regulated by the matrix protein, VP40, which is a peripheral protein that associates with anionic lipids at the inner leaflet of the plasma membrane.
Yogesh Narkhede, Roopashi Saxena, Tej Sharma, Jacob P. Conarty, Valentina Toro Ramirez, Balindile B. Motsa, Souad Amiar, Sheng Li, Prem P. Chapagain, Olaf Wiest, Robert V. Stahelin   +10 more
wiley   +1 more source

Marburg Virus VP40 Antagonizes Interferon Signaling in a Species-Specific Manner [PDF]

Journal of Virology, 2011
ABSTRACT Marburgviruses are zoonotic pathogens that cause lethal hemorrhagic fever in humans and nonhuman primates. However, they do not cause lethal disease in immunocompetent mice unless they are adapted to this species.
Charalampos Valmas, Christopher F. Basler   +1 more
openaire   +2 more sources

Identification of Prospective Ebola Virus VP35 and VP40 Protein Inhibitors from Myxobacterial Natural Products

Biomolecules
The Ebola virus (EBOV) is a lethal pathogen causing hemorrhagic fever syndrome which remains a global health challenge. In the EBOV, two multifunctional proteins, VP35 and VP40, have significant roles in replication, virion assembly, and budding from the
Muhammad Hayat, Tian Gao, Ying Cao, Muhammad Rafiq, Li Zhuo, Yue-Zhong Li   +5 more
doaj   +1 more source

High-resolution Crystal Structure of Dimeric VP40 FromSudan ebolavirus [PDF]

Journal of Infectious Diseases, 2015
Ebolaviruses cause severe hemorrhagic fever. Central to the Ebola life cycle is the matrix protein VP40, which oligomerizes and drives viral budding. Here we present the crystal structure of the Sudan virus (SUDV) matrix protein. This structure is higher resolution (1.6 Å) than previously achievable.
Erica Ollmann Saphire, Jessica F. Bruhn, Amy C. Raymond, Matthew C. Clifton, Peter J. Myler, Terry L. Webb, Thomas E. Edwards, Kateri Atkins, Donald D. Lorimer, Ruth Baydo   +9 more
openaire   +3 more sources

Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice

Microorganisms, 2020
Kunjin virus (KUNV) is an attenuated strain of the severe neurotropic West Nile virus (WNV). The virus has a single-strand positive-sense RNA genome that encodes a polyprotein.
Pham-Tue-Hung Tran, Naveed Asghar, Urban Höglund, Olivia Larsson, Lars Haag, Ali Mirazimi, Magnus Johansson, Wessam Melik   +7 more
doaj   +1 more source

High-throughput virtual screening and docking studies of matrix protein vp40 of ebola virus [PDF]

Bioinformation, 2013
Ebolavirus, a member of the Filoviridae family of negative-sense RNA viruses, causes severe haemorrhagic fever leading up to 90% lethality. Ebolavirus matrix protein VP40 is involved in the virus assembly and budding process. The RNA binding pocket of VP40 is considered as the drug target site for structure based drug design.
Waheeta Hopper, Thangaraju Tamilvanan
openaire   +3 more sources

Marburg virus exploits the Rab11-mediated endocytic pathway in viral-particle production

Microbiology Spectrum
Filoviruses produce viral particles with characteristic filamentous morphology. The major viral matrix protein, VP40, is trafficked to the plasma membrane and promotes viral particle formation and subsequent viral egress.
Wakako Furuyama, Kento Yamada, Miako Sakaguchi, Andrea Marzi, Asuka Nanbo   +4 more
doaj   +1 more source

Temporal evolution of the humoral antibody response after Ebola virus disease in Guinea: a 60-month observational prospective cohort study

The Lancet Microbe, 2021
Summary: Background: Insufficient long-term data are available on antibody kinetics in survivors of Ebola virus disease (EVD). Likewise, few studies, with very small sample sizes, have investigated cross-reactions between Ebolavirus spp.
Mamadou Saliou Kalifa Diallo, MSc, Ahidjo Ayouba, PhD, Alpha Kabinet Keita, PhD, Guillaume Thaurignac, MSc, Mamadou Saliou Sow, MD, Cécé Kpamou, MSc, Thierno Alimou Barry, MD, Philippe Msellati, PhD, Jean-François Etard, PhD, Martine Peeters, PhD, René Ecochard, ProfPhD, Eric Delaporte, ProfPhD, Abdoulaye Toure, PhD, Ahidjo Ayouba, Sylvain Baize, Kaba Bangoura, Alimou Barry, Moumié Barry, Mamoudou Cissé, Mohammed Cissé, Eric Delaporte, Jean-François Delfraissy, Christelle Delmas, Alice Desclaux, Saliou Bella Diallo, Mamadou Safiatou Diallo, Mariama Sadjo Diallo, Jean-François Étard, Cécile Etienne, Ousmane Faye, Ibrahima Fofana, Bruno Granouillac, Suzanne Izard, Djenaba Kassé, Alpha Kabinet Keita, Sakoba Keita, Lamine Koivogui, Cécé Kpamou, Christine Lacarabaratz, Sandrine Leroy, Claire Levy Marchal, Yves Levy, N'Fally Magassouba, Laura March, Vincent Mendiboure, Philippe Msellati, Harissatou Niane, Martine Peeters, Yves-Marie Pers, Hervé Raoul, Sidi Lamine Sacko, Ibrahima Savané, Mamadou Saliou Sow, Bernard Taverne, Abdoulaye Touré, Fodé Amara Traoré, Falaye Traoré, Yamoussa Youla, Yazdan Yazdanpanah   +58 more
doaj  

Regulating the human HECT E3 ligases [PDF]

, 2018
Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT (homologous to E6AP C terminus) family is critical in controlling diverse physiological pathways.
Distel, B. (Ben), Sluimer, J. (Jasper)
core   +3 more sources