Results 101 to 110 of about 2,213 (186)

Development of a Crystallographic Screening to Identify Sudan Virus VP40 Ligands

ACS Omega
The matrix protein VP40 of the highly pathogenic Sudan virus (genus Orthoebolavirus) is a multifunctional protein responsible for the recruitment of viral nucleocapsids to the plasma membrane and the budding of infectious virions. In addition to its role in assembly, VP40 also downregulates viral genome replication and transcription.
Anke-Dorothee Werner, Nils Krapoth, Michael J. Norris, Andreas Heine, Gerhard Klebe, Erica Ollmann Saphire, Stephan Becker   +6 more
openaire   +3 more sources

Monoclonal Antibodies and Recombinant Proteins for Immune-Diagnostics of Ebola Virus Disease

Проблемы особо опасных инфекций, 2015
The review summarizes the literature data on the studies of viral antigens and antibodies, specific to Ebola virus, suitable for the development of a test-system for immune-diagnostics of the disease caused by them.
E. I. Kazachinskaya, Yu. V. Nikonorova, V. B. Loktev   +2 more
doaj   +1 more source

Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]

, 2016
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline, Dudman, Susanne Gjeruldsen, Fomsgaard, Anders, Karlberg, Helen, Kran, Anne Marte Bakken, Lindegren, Gunnel, Mirazimi, Ali, Rosenstierne, Maiken Wors\uf8e, Salata, Cristiano, Stoltz, Malin Lundahl   +9 more
core   +1 more source

Ebolavirus replication and Tetherin/BST-2

Frontiers in Microbiology, 2012
Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Tai Forest ebolavirus (TFEBOV), Bundibugyo ebolavirus (BEBOV), and Reston ebolavirus (REBOV)
Jiro eYasuda
doaj   +1 more source

Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity [PDF]

, 2014
Background Ebolaviruses cause a severe and often fatal haemorrhagic fever in humans, with some species such as Ebola virus having case fatality rates approaching 90%. Currently, the worst Ebola virus outbreak since the disease was discovered is occurring
A Groseth, A Pichlmair, A Sanchez, A Topfer, AA Chepurnov, B Hudjetz, BM Connolly, C Trapnell, Christiane Hertz-Fowler, Cyril Empig, D Falzarano, David A Matthews, E Adu-Gyamfi, E Ryabchikova, E Subbotina, EM Leroy, ET Bowen, F Feldmann, G Gabriel, G Liu, GA Marsh, GS Mohan, H Ebihara, HM Weingartl, I Garcia-Dorival, Irene Taylor, Isabel García-Dorival, John Kenny, John N Barr, JR Kugelman, Julian A Hiscox, Kara Corbin-Lickfett, KM Johnson, Kyle Schlunegger, LJ Reed, LR Baden, M Linster, M Martin, M Mateo, M Mehedi, M Mehedi, MA Larkin, Miles W Carroll, N Biedenkopf, N van Doremalen, NA Twenhafel, Neil Hall, O Martinez, Roger Hewson, S Baize, S Herfst, S Pattyn, SA Carroll, SP Reid, Stuart D Dowall, T Hoenen, VA Volchkova, VE Volchkov, VE Volchkov, W Xu, WHO   +60 more
core   +1 more source

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding [PDF]

Journal of Virology, 2016
ABSTRACT Ebola virus (EBOV) and Marburg virus (MARV) belong to the Filoviridae family and can cause outbreaks of severe hemorrhagic fever, with high mortality rates in humans. The EBOV VP40 (eVP40) and MARV VP40 (mVP40) matrix proteins play a central role in virion assembly and egress, such that ...
Han, Z, Sagum, C.A, Bedford, M.T, Sidhu, S.S, Sudol, M, Harty, R.N   +5 more
openaire   +3 more sources

A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures

Viruses, 2020
Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western Africa.
Ryan P. Bennett, Courtney L. Finch, Elena N. Postnikova, Ryan A. Stewart, Yingyun Cai, Shuiqing Yu, Janie Liang, Julie Dyall, Jason D. Salter, Harold C. Smith, Jens H. Kuhn   +10 more
doaj   +1 more source

Epitope-based peptide vaccine against Bombali Ebolavirus viral protein 40: An immunoinformatics combined with molecular docking studies

Informatics in Medicine Unlocked, 2021
Bombali Ebolavirus belongs to the RNA group of viruses which causes lethal hemorrhagic fever with a high mortality rate. Despite these facts, yet there is no approved vaccine have been developed for the eradication of Bombali Ebolavirus infections ...
Mujahed I. Mustafa, Shaza W. Shantier, Miyssa I. Abdelmageed, Abdelrafie M. Makhawi   +3 more
doaj  

In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40.

PLoS ONE
VP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in the viral lifecycle.
Abdullah R Alanzi, Mohammed F Alajmi, Mohammed S Al-Dosari, Mohammad K Parvez, Moneerah J Alqahtani   +4 more
doaj   +1 more source

Full-length Ebola glycoprotein accumulates in the endoplasmic reticulum

Virology Journal, 2011
The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens.
Bhattacharyya Suchita, Hope Thomas J
doaj   +1 more source