PLoS Pathogens, 2020 Ebola (EBOV) and Marburg (MARV) are members of the Filoviridae family, which continue to emerge and cause sporadic outbreaks of hemorrhagic fever with high mortality rates.
Ziying Han +14 more
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The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness [PDF]
, 2017 Marburg virus (MARV) is a highly pathogenic virus that causes severe, often lethal diseases specifically in humans and non-human primates. In rodents MARV is non-pathogenic.
Köhler, Alexander
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The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties
Viruses, 2020 Viral protein 24 (VP24) from Ebola virus (EBOV) was first recognized as a minor matrix protein that associates with cellular membranes. However, more recent studies shed light on its roles in inhibiting viral genome transcription and replication ...
Yuan Su, Robert V. Stahelin
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, 2020 Characteristics of the family Filoviridae and the Ebola virus: an update of its implications in the human population The family Filoviridae is integrated by a group of filamentous RNA viruses that cause severe hemorrhagic fevers in primates and other ...
Burgueño-Sosa, E. +3 more
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Membrane association and localization dynamics of the Ebola virus matrix protein VP40
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2017 The Ebola virus matrix protein VP40 is a major structural protein that provides the scaffolding for new Ebola virus particles. For this, VP40 is first trafficked to the lower leaflet of the plasma membrane (PM) in its dimeric form. Once associated with the PM, the VP40 dimers undergo structural rearrangements and oligomerize into hexamers and filaments
Jeevan B. Gc +2 more
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Quantification and a Molecular Dynamics Study of Viral Membrane Lipids through Plasmon Coupling Microscopy [PDF]
, 2015 Phosphatidylserine (PS) and monosialotetrahexosylganglioside (G_M1) are examples of two host-derived lipids in the membrane of enveloped virus particles that are known to contribute to virus attachment, uptake, and ultimately dissemination.
Feizpour, Amin, Reinhard, Björn
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BMC Microbiology, 2003 Background Ebola virus causes severe, often fatal hemorrhagic fever in humans. The mechanism of escape from cellular anti-viral mechanisms is not yet fully understood.
Szekely Laszlo +2 more
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Cell-to-cell infection, cell-cell fusion and production of ebolavirus : mechanisms of action and cellular modulators [PDF]
Ebolavirus (EBOV), a member of the Filoviridae family, is a deadly non-segment negative-sense RNA virus that causes hemorrhagic fever among human and other species; the fatality rate can be up to 80%.
Miao, Chunhui
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Discovery of potential drug-like compounds against Viral protein (VP40) of Marburg Virus using pharmacophoric based virtual screening from ZINC database [PDF]
, 2021 Sameer Quazi +4 more
openalex +1 more source
Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data [PDF]
, 2016 Background Ebola virus has been detected in semen of Ebola virus disease survivors after recovery. Liberia’s Men’s Health Screening Program (MHSP) off ers Ebola virus disease survivors semen testing for Ebola virus.
Baller, April +7 more
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