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ROLE OF VP40 IN EBOLA ASSEMBLY
2001The VP40 protein of Ebola virus (EBOV) is thought to be a key component in the assembly of infectious virions. If so, one might predict that when expressed alone, it would form virus-like particles. To test this possibility, we created a plasmid that expressed VP40 under the control of a CMV promoter. Transfection of mammalian cells with this construct
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VP40 Comprehensive Evaluation Of Islet Transplantation For Type I Diabetes
International Journal of Technology Assessment in Health Care, 2017INTRODUCTION:Despite several therapeutic options existing for the patients with type I diabetes, the patients are still at high risk for severe acute and chronic complications (1). Pancreatic islet transplantation is a promising therapy to achieve good glycemic control with no or little additional insulin (2).
Danni Chen, Kun Xiong, Di Xue
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Characterization of the Unconventional Secretion of the Ebola Matrix Protein VP40
2016While most secreted proteins use the classical endoplasmic reticulum (ER)-Golgi secretion pathway to reach the extracellular medium, a few proteins are secreted through unconventional secretary pathways. Viral proteins can be secreted through unconventional secretion pathways.
Reynard, Olivier, Mateo, Mathieu
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Expression and Immunogenicity of VP40 Protein of ZEBOV.
Archives of Iranian medicine, 2017EBOV outbreaks continue to threaten the world due to the absence of effective vaccines and therapeutics. Easy-to-use and rapid diagnostic tests for EBOV are highly desired for prevention and control of the EVD epidemic.Escherichia coli expression system was used to express VP40 protein of Zaire Ebola virus (ZEBOV) as water-soluble protein upon ...
Yinbiao, Wang +7 more
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Targeting Lipid Metabolism to Inhibit Ebola VP40 Mediated Viral Budding
The FASEB Journal, 2017In 2014, an international public health emergency was declared when an Ebola virus outbreak claimed the lives of thousands, resulting in the most fatal, widespread and prolonged outbreak of Ebola virus recorded in history. Although 40 years have passed since the initial outbreak, numerous vaccines and post‐exposure therapeutics have entered phase I, II
Monica Leigh Husby, Robert Stahelin
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Expression of the VP40 antigen from the Zaire ebolavirus in tobacco plants
Planta, 2017The plant cell is able to produce the VP40 antigen from the Zaire ebolavirus , retaining the antigenicity and the ability to induce immune responses in BALB/c mice. The recent Ebola outbreak evidenced the need for having vaccines approved for human use. Herein we report the expression of the VP40 antigen from the Ebola virus as an initial effort in the
Elizabeth, Monreal-Escalante +5 more
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Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction
2017Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of causing severe hemorrhagic fever with up to 80-90% mortality rates. The most recent outbreak of EBOV in West Africa starting in 2014 resulted in over 11,300 deaths; however, long-lasting persistence and recurrence in survivors has been documented, potentially leading
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