Computational and experimental identification of keystone interactions in Ebola virus matrix protein
Protein Science, Volume 33, Issue 5, May 2024.Abstract The Ebola virus (EBOV) is a lipid‐enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV is regulated by the matrix protein, VP40, which is a peripheral protein that associates with anionic lipids at the inner leaflet of the plasma membrane.
Yogesh B. Narkhede +10 more
wiley +3 more sources
Development of a Novel, Highly Sensitive System for Evaluating Ebola Virus Particle Formation [PDF]
VirusesEbola virus (EBOV) causes severe hemorrhagic fevers in humans, and effective countermeasures remain limited. The EBOV-encoded major matrix protein VP40 is essential for viral assembly, budding, and particle release, making it a promising target for ...
Wakako Furuyama +3 more
doaj +2 more sources
Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress [PDF]
Journal of Virology, 2017 ABSTRACT Ebola virus (EBOV) is a member of the Filoviridae family and the cause of hemorrhagic fever outbreaks. The EBOV VP40 (eVP40) matrix protein is the main driving force for virion assembly and budding.
Ziying Han +11 more
openalex +3 more sources
Měnglà Virus VP40 Localizes to the Nucleus and Impedes the RIG-I Signaling Pathway [PDF]
VirusesMěnglà virus (MLAV) is a member of the genus Dianlovirus in the family Filoviridae, which also includes Ebola virus (EBOV) and Marburg virus (MARV). Whether MLAV poses a threat to human health is uncertain.
Joyce Sweeney Gibbons +6 more
doaj +2 more sources
PLoS ONE, 2012 The matrix protein VP40 coordinates numerous functions in the viral life cycle of the Ebola virus. These range from the regulation of viral transcription to morphogenesis, packaging and budding of mature virions.
Leslie P Silva +4 more
doaj +3 more sources
Identification of novel small chemical compounds that inhibit Ebola virus VP40-mediated virus-like particle production [PDF]
Virus ResearchThe central role of Ebola virus (EBOV) VP40 in nascent virion assembly and budding from infected host cells makes it an important therapeutic target. Previously, we reported two novel chemical compounds (NUSU#1 and NUSU#2) that inhibit EBOV VP40-mediated
Tomoko Tsuruta +4 more
doaj +2 more sources
Viruses, 2020 Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host ...
Kaveesha J. Wijesinghe +7 more
doaj +3 more sources
Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants
PLoS Pathogens, 2021 Six ebolavirus species are reported to date, including human pathogens Bundibugyo virus (BDBV), Ebola virus (EBOV), Sudan virus (SUDV), and Taï Forest virus (TAFV); non-human pathogen Reston virus (RESTV); and the plausible Bombali virus (BOMV).
Qingbo Shu +5 more
doaj +5 more sources
Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments [PDF]
Biochemical and Biophysical Research Communications, 2017 Ebola virus infections cause hemorrhagic fever that often results in very high fatality rates. In addition to exploring vaccines, development of drugs is also essential for treating the disease and preventing the spread of the infection. The Ebola virus matrix protein VP40 exists in various conformational and oligomeric forms and is a potential ...
B. Jeevan +6 more
openalex +4 more sources
Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction [PDF]
Frontiers in Microbiology, 2018 Corrigendum to: Ebola VP40 in Exosomes Can Cause Immune Cell ...
Michelle L. Pleet +13 more
openalex +3 more sources