Results 11 to 20 of about 2,213 (186)
Membrane Binding and Bending in Ebola VP40 Assembly and Egress [PDF]
Frontiers in Microbiology, 2014 Lipid-enveloped viruses contain a lipid bilayer coat that protects their genome and helps to facilitate entry into the host cell. Filoviruses are lipid-enveloped viruses that have up to 90% clinical fatality and include Marbug (MARV) and Ebola (EBOV ...
Robert V Stahelin, Robert V Stahelin
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Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction [PDF]
Frontiers in Microbiology, 2016 Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of causing severe hemorrhagic fever with up to 80–90% mortality rates.
Michelle L. Pleet +16 more
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Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers [PDF]
eLife, 2020 Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped virions. This process is achieved by the matrix protein VP40. When expressed alone, VP40 induces budding of filamentous virus-like particles, suggesting that localization
William Wan +8 more
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Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments [PDF]
Biochemical and Biophysical Research Communications, 2017 Ebola virus infections cause hemorrhagic fever that often results in very high fatality rates. In addition to exploring vaccines, development of drugs is also essential for treating the disease and preventing the spread of the infection.
Bhattarai, Nisha +6 more
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Domain rearrangement and denaturation in Ebola virus protein VP40 [PDF]
AIP Advances, 2018 The VP40 protein plays a critical role in coordinating the virion assembly, budding, and replication of the Ebola virus. Efforts have been made in recent years to understand various aspects of VP40 structure, dynamics, and function such as assembly of ...
Rudramani Pokhrel +5 more
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Obtaining and Immunologic Characterization of Filoviruses Recombinant Proteins VP40 and NP
Проблемы особо опасных инфекций, 2010 Full-size genes coding matrix proteins VP40 of Ebola virus (VE) and Marburg virus (VM) and nucleoprotein (NP) of VE were cloned. These genes expression in Escherichia coli and purification of their products by affinity chromatography using Ni-NTA agarose
A. V. Ivanova +7 more
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Unconventional Secretion of Ebola Virus Matrix Protein VP40 [PDF]
The Journal of Infectious Diseases, 2011 The Ebola virus matrix protein VP40 plays an essential role in virus assembly and budding. In this study we reveal that transient VP40 expression results in the release into the culture medium of substantial amounts of soluble monomeric VP40 in addition to the release of virus-like particles containing an oligomeric form of this protein as previously ...
Olivier Reynard +7 more
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Vesicular Release of Ebola Virus Matrix Protein VP40
Virology, 2001 We have analysed the expression and cellular localisation of the matrix protein VP40 from Ebola virus. Full-length VP40 and an N-terminal truncated construct missing the first 31 residues [VP40(31-326)] both locate to the plasma membrane of 293T cells when expressed transiently, while a C-terminal truncation of residues 213 to 326 [VP40(31-212)] shows ...
Joanna Timmins +3 more
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Crystal structure of the matrix protein VP40 from Ebola virus [PDF]
The EMBO Journal, 2000 Ebola virus maturation occurs at the plasma membrane of infected cells and involves the clustering of the viral matrix protein VP40 at the assembly site as well as its interaction with the lipid bilayer. Here we report the X-ray crystal structure of VP40 from Ebola virus at 2.0 A resolution.
Andréa Dessen
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Ebola Virus VP40-Induced Particle Formation and Association with the Lipid Bilayer [PDF]
Journal of Virology, 2001 ABSTRACT Viral protein 40 (VP40) of Ebola virus appears equivalent to matrix proteins of other viruses, yet little is known about its role in the viral life cycle. To elucidate the functions of VP40, we investigated its ability to induce the formation of membrane-bound particles when it was expressed apart from other viral proteins.
Luke D. Jasenosky +3 more
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