Exploratory Temporal and Evolutionary Insights into the Filoviridae Family Through Multiprotein Phylogeny [PDF]
MicroorganismsFiloviruses are among the most lethal viral human pathogens known, with significant relevance to public health, yet their evolutionary history remains poorly resolved.
Thiago S. Messias +15 more
doaj +2 more sources
A fatty acid-ordered plasma membrane environment is critical for Ebola virus matrix protein assembly and budding [PDF]
Journal of Lipid ResearchPlasma membrane (PM) domains and order phases have been shown to play a key role in the assembly, release, and entry of several lipid-enveloped viruses. In the present study, we provide a mechanistic understanding of the Ebola virus (EBOV) matrix protein
Souad Amiar +4 more
doaj +2 more sources
Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress [PDF]
VirusesFiloviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Loveleena K. Anand +4 more
doaj +2 more sources
Ebola virus matrix protein VP40 triggers inflammatory responses linked to the ebolavirus virulence [PDF]
Proc Natl Acad Sci U S ASatoko Yamaoka +12 more
openalex +2 more sources
Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals [PDF]
Protein Science, Volume 34, Issue 1, January 2025.Abstract The ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to ...
Fernando Montero +17 more
wiley +2 more sources
Marburg virus exploits the Rab11-mediated endocytic pathway in viral-particle production [PDF]
Microbiology SpectrumFiloviruses produce viral particles with characteristic filamentous morphology. The major viral matrix protein, VP40, is trafficked to the plasma membrane and promotes viral particle formation and subsequent viral egress.
Wakako Furuyama +4 more
doaj +2 more sources
Impact of Ebola virus nucleoprotein on VP40 virus-like particle production: a computational approach [PDF]
Communications BiologyEbola virus (EBOV) matrix protein VP40 can assemble and bud as virus-like particles (VLPs) when expressed alone in mammalian cells. Nucleoprotein (NP) could be recruited to VLPs as inclusion body (IB) when co-expressed, and increase VLP production ...
Xiao Liu +2 more
doaj +2 more sources
In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40. [PDF]
PLoS ONEVP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in the viral lifecycle.
Abdullah R Alanzi +4 more
doaj +2 more sources
Development of a Crystallographic Screening to Identify Sudan Virus VP40 Ligands [PDF]
ACS OmegaThe matrix protein VP40 of the highly pathogenic Sudan virus (genus Orthoebolavirus) is a multifunctional protein responsible for the recruitment of viral nucleocapsids to the plasma membrane and the budding of infectious virions. In addition to its role in assembly, VP40 also downregulates viral genome replication and transcription.
Anke-Dorothee Werner +6 more
openaire +4 more sources
Identification of Prospective Ebola Virus VP35 and VP40 Protein Inhibitors from Myxobacterial Natural Products [PDF]
BiomoleculesThe Ebola virus (EBOV) is a lethal pathogen causing hemorrhagic fever syndrome which remains a global health challenge. In the EBOV, two multifunctional proteins, VP35 and VP40, have significant roles in replication, virion assembly, and budding from the
Muhammad Hayat +5 more
doaj +2 more sources