Results 31 to 40 of about 2,832 (180)

Identification of potential VP40 inhibitor of Marburg virus through molecular docking, pharmacokinetic analysis and molecular dynamics simulation [PDF]

Sci Rep
Rohit Das, Anil Bhattarai, Buddhiman Tamang, Nagendra Thakur   +3 more
openalex   +2 more sources

P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity

PLoS Pathogens, 2021
The final stage of Ebola virus (EBOV) replication is budding from host cells, where the matrix protein VP40 is essential for driving this process. Many post-translational modifications such as ubiquitination are involved in VP40 egress, but acetylation ...
Linliang Zhang, Shixiong Zhou, Majuan Chen, Jie Yan, Yi Yang, Linjuan Wu, Dongning Jin, Lei Yin, Mingzhou Chen, Yali Qin   +9 more
doaj   +2 more sources

Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors

International Journal of Molecular Sciences, 2023
The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in primates. However, there are no regulatorily approved drugs against the Ebola virus disease (EVD). The highly virulent and lethal nature of EVD highlights the need to develop therapeutic agents.
Emmanuel Broni, Carolyn Ashley, Joseph Adams, Hammond Manu, Ebenezer Aikins, Mary Okom, Whelton A. Miller, Michael D. Wilson, Samuel K. Kwofie   +8 more
openaire   +2 more sources

Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form

Cell Reports, 2021
Summary: The Ebola virus matrix protein VP40 forms distinct structures linked to distinct functions in the virus life cycle. Dimeric VP40 is a structural protein associated with virus assembly, while octameric, ring-shaped VP40 is associated with ...
Sara Landeras-Bueno, Hal Wasserman, Glenn Oliveira, Zachary L. VanAernum, Florian Busch, Zhe Li Salie, Vicki H. Wysocki, Kristian Andersen, Erica Ollmann Saphire   +8 more
doaj   +1 more source

VP40 Octamers Are Essential for Ebola Virus Replication [PDF]

Journal of Virology, 2005
ABSTRACT Matrix protein VP40 of Ebola virus is essential for virus assembly and budding. Monomeric VP40 can oligomerize in vitro into RNA binding octamers, and the crystal structure of octameric VP40 has revealed that residues Phe125 and Arg134 are the most important residues for the coordination of a short single-stranded RNA.
Thomas, Hoenen, Viktor, Volchkov, Larissa, Kolesnikova, Eva, Mittler, Joanna, Timmins, Michelle, Ottmann, Olivier, Reynard, Stephan, Becker, Winfried, Weissenhorn   +8 more
openaire   +2 more sources

Unconventional Secretion of Ebola Virus Matrix Protein VP40 [PDF]

The Journal of Infectious Diseases, 2011
The Ebola virus matrix protein VP40 plays an essential role in virus assembly and budding. In this study we reveal that transient VP40 expression results in the release into the culture medium of substantial amounts of soluble monomeric VP40 in addition to the release of virus-like particles containing an oligomeric form of this protein as previously ...
Reynard, Olivier, Reid, St Patrick, Page, Audrey, Mateo, Mathieu, Alazard-Dany, Nathalie, Raoul, Hervé, Basler, Christopher, Volchkov, Viktor   +7 more
openaire   +3 more sources

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress [PDF]

Bioorganic & Medicinal Chemistry Letters, 2016
We prepared a series of quinoxalin-2-mercapto-acetyl-urea analogs and evaluated them for their ability to inhibit viral egress in our Marburg and Ebola VP40 VLP budding assays in HEK293T cells. We also evaluated selected compounds in our bimolecular complementation assay (BiMC) to detect and visualize a Marburg mVP40-Nedd4 interaction in live mammalian
H. Marie Loughran, Ziying Han, Jay E. Wrobel, Sarah E. Decker, Gordon Ruthel, Bruce D. Freedman, Ronald N. Harty, Allen B. Reitz   +7 more
openaire   +2 more sources

The neglected continuously emerging Marburg virus disease in Africa: A global public health threat

Health Science Reports, Volume 6, Issue 11, November 2023., 2023
Abstract Background and Aim Severe viral hemorrhagic fever (VHF) is caused by Marburg virus which is a member of the Filoviridae (filovirus) family. Many Marburg virus disease (MVD) outbreaks are reported in five decades. A major notable outbreak with substantial reported cases of infections and deaths was in 2022 in Uganda.
Devang Srivastava, Lakshmi Venkata Simhachalam Kutikuppala, Pooja Shanker, Rudra Narayan Sahoo, Gurudutta Pattnaik, Rasmita Dash, Venkataramana Kandi, Azaj Ansari, Snehasish Mishra, Dhruv N. Desai, Ranjan K. Mohapatra, Ali A. Rabaan, Md. Kudrat‐E‐Zahan   +12 more
wiley   +1 more source

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. [PDF]

PLoS Pathogens, 2017
Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains
Jingjing Liang, Cari A Sagum, Mark T Bedford, Sachdev S Sidhu, Marius Sudol, Ziying Han, Ronald N Harty   +6 more
doaj   +1 more source

Ribonucleoprotein transport in Negative Strand RNA viruses

Biology of the Cell, Volume 115, Issue 1, January 2023., 2023
The genome replication of Negative‐sense, single‐stranded RNA viruses most‐often segregate in membrane‐less environments called inclusion bodies (IBs). These “organelles” usually locate far from the cell surface from where new virions are released. Here, for each viral family, we discuss how the genome progeny is transported from the IBs to reach the ...
Cédric Diot, Gina Cosentino, Marie‐Anne Rameix‐Welti   +2 more
wiley   +1 more source