Results 31 to 40 of about 2,213 (186)
Ribonucleoprotein transport in Negative Strand RNA viruses
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 The genome replication of Negative‐sense, single‐stranded RNA viruses most‐often segregate in membrane‐less environments called inclusion bodies (IBs). These “organelles” usually locate far from the cell surface from where new virions are released. Here, for each viral family, we discuss how the genome progeny is transported from the IBs to reach the ...
Cédric Diot +2 more
wiley +1 more source
Regulation of Ebola virus VP40 matrix protein by SUMO [PDF]
Scientific Reports, 2016 AbstractThe matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and transcription, and has an intrinsic ability to form virus-like particles. The elucidation of the regulation of VP40 functions is essential to identify mechanisms to inhibit viral ...
Manuel S. Rodriguez +14 more
openaire +4 more sources
BioMed Research International, Volume 2023, Issue 1, 2023., 2023 A hemorrhagic fever caused by the Marburg virus (MARV) belongs to the Filoviridae family and has been classified as a risk group 4 pathogen. To this day, there are no approved effective vaccinations or medications available to prevent or treat MARV infections.
Faisal F. Albaqami +7 more
wiley +1 more source
Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. [PDF]
PLoS Pathogens, 2017 Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains
Jingjing Liang +6 more
doaj +1 more source
Biotechnology Journal, Volume 17, Issue 11, November 2022., 2022 Graphical Abstract and Lay Summary Exosomes are spherical structures less than 150 nm in diameter that are released from the plasma membrane of cells, carrying cargo within them. They play a key role in cell‐cell communication and are involved in modulating many cellular processes, can be biomarkers of health and disease, and have enormous potential ...
Laura E Dyball, C. Mark Smales
wiley +1 more source
Membrane Penetrating Ability of Ebola Matrix Protein, VP40 [PDF]
Biophysical Journal, 2013 Ebola from the filoviridae family of viruses causes severe and mostly fatal hemorrhagic fevers in primates and has been listed as a category IV pathogen by the NIH. Viral Protein 40 (VP40), the major matrix protein of Ebola virus, regulates the assembly and budding of the virus and alone harbors the ability to form virus-like particles (VLPs) from ...
Emmanuel Adu-Gyamfi +4 more
openaire +2 more sources
Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants
PLoS Pathogens, 2021 Six ebolavirus species are reported to date, including human pathogens Bundibugyo virus (BDBV), Ebola virus (EBOV), Sudan virus (SUDV), and Taï Forest virus (TAFV); non-human pathogen Reston virus (RESTV); and the plausible Bombali virus (BOMV).
Qingbo Shu +5 more
doaj +2 more sources
Journal of Medical Virology, Volume 94, Issue 7, Page 3263-3269, July 2022., 2022 Abstract The ability of viruses in the Filoviridae family (Ebola virus [EBOV] and Marburg virus [MARV]) to cause severe human disease and their pandemic potential makes all emerging filoviral pathogens a concern to humanity. Měnglà virus (MLAV) belonging to the new genus Dianlovirus was recently discovered in the liver of bats from Měnglà County ...
Laura Cooper +2 more
wiley +1 more source
The VP35 and VP40 proteins of filoviruses [PDF]
FEBS Letters, 1993 The fragments of genomic RNA sequences of Marburg (MBG) and Ebola (EBO) viruses are reported. These fragments were found to encode the VP35 and VP40 proteins. The canonic sequences were revealed before and after each open reading frame. It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA ...
Alexander Bukreyev +3 more
openaire +3 more sources
Automated Laser‐Transfer Synthesis of High‐Density Microarrays for Infectious Disease Screening
Advanced Materials, Volume 34, Issue 23, June 9, 2022., 2022 An automated laser‐based synthesis machine is presented, combining laser‐induced forward transfer and robotics to perform parallel chemistry in the microarray format with up to 10 000 individual reactions cm−2. By developing an optimization pipeline, peptide microarrays with thousands of different sequences can be synthesized in high yield to study the
Grigori Paris +15 more
wiley +1 more source