Results 41 to 50 of about 2,832 (180)

Computational Modeling and Evaluation of Potential mRNA and Peptide‐Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever

BioMed Research International, Volume 2023, Issue 1, 2023., 2023
A hemorrhagic fever caused by the Marburg virus (MARV) belongs to the Filoviridae family and has been classified as a risk group 4 pathogen. To this day, there are no approved effective vaccinations or medications available to prevent or treat MARV infections.
Faisal F. Albaqami, Ali Altharawi, Hassan N. Althurwi, Khalid M. Alharthy, Muhammad Qasim, Ziyad Tariq Muhseen, Muhammad Tahir ul Qamar, Syed Hassan   +7 more
wiley   +1 more source

Association of Ebola Virus Matrix Protein VP40 with Microtubules [PDF]

Journal of Virology, 2005
ABSTRACT Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for many viruses. A variety of viral proteins have been identified that interact with microtubules, either directly or via a microtubule ...
Gordon, Ruthel, Gretchen L, Demmin, George, Kallstrom, Melodi P, Javid, Shirin S, Badie, Amy B, Will, Timothy, Nelle, Rowena, Schokman, Tam L, Nguyen, John H, Carra, Sina, Bavari, M Javad, Aman   +11 more
openaire   +2 more sources

Exosomes: Biogenesis, targeting, characterization and their potential as "Plug & Play" vaccine platforms

Biotechnology Journal, Volume 17, Issue 11, November 2022., 2022
Graphical Abstract and Lay Summary Exosomes are spherical structures less than 150 nm in diameter that are released from the plasma membrane of cells, carrying cargo within them. They play a key role in cell‐cell communication and are involved in modulating many cellular processes, can be biomarkers of health and disease, and have enormous potential ...
Laura E Dyball, C. Mark Smales
wiley   +1 more source

Regulation of Ebola virus VP40 matrix protein by SUMO [PDF]

Scientific Reports, 2016
AbstractThe matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and transcription, and has an intrinsic ability to form virus-like particles. The elucidation of the regulation of VP40 functions is essential to identify mechanisms to inhibit viral ...
Baz-Martínez, Maite, El Motiam, Ahmed, Ruibal, Paula, Condezo Castro, Gabriela Nérida, de la Cruz Herrera, Carlos F., Lang, Valerie, Collado, Manuel, San Martín, Carmen, Rodríguez, Manuel S., Muñoz Fontela, Cesar, Rivas, Carmen   +10 more
openaire   +3 more sources

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

eLife, 2020
Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped virions. This process is achieved by the matrix protein VP40. When expressed alone, VP40 induces budding of filamentous virus-like particles, suggesting that localization
William Wan, Mairi Clarke, Michael J Norris, Larissa Kolesnikova, Alexander Koehler, Zachary A Bornholdt, Stephan Becker, Erica Ollmann Saphire, John AG Briggs   +8 more
doaj   +1 more source

Comparative analyses of small molecule and antibody inhibition on glycoprotein‐mediated entry of Měnglà virus with other filoviruses

Journal of Medical Virology, Volume 94, Issue 7, Page 3263-3269, July 2022., 2022
Abstract The ability of viruses in the Filoviridae family (Ebola virus [EBOV] and Marburg virus [MARV]) to cause severe human disease and their pandemic potential makes all emerging filoviral pathogens a concern to humanity. Měnglà virus (MLAV) belonging to the new genus Dianlovirus was recently discovered in the liver of bats from Měnglà County ...
Laura Cooper, Jazmin Galvan Achi, Lijun Rong   +2 more
wiley   +1 more source

Automated Laser‐Transfer Synthesis of High‐Density Microarrays for Infectious Disease Screening

Advanced Materials, Volume 34, Issue 23, June 9, 2022., 2022
An automated laser‐based synthesis machine is presented, combining laser‐induced forward transfer and robotics to perform parallel chemistry in the microarray format with up to 10 000 individual reactions cm−2. By developing an optimization pipeline, peptide microarrays with thousands of different sequences can be synthesized in high yield to study the
Grigori Paris, Jasmin Heidepriem, Alexandra Tsouka, Yuxin Liu, Daniela S. Mattes, Sandra Pinzón Martín, Pietro Dallabernardina, Marco Mende, Celina Lindner, Robert Wawrzinek, Christoph Rademacher, Peter H. Seeberger, Frank Breitling, Frank Ralf Bischoff, Timo Wolf, Felix F. Loeffler   +15 more
wiley   +1 more source

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Advanced Science, Volume 9, Issue 17, June 13, 2022., 2022
This review summarizes the latest development of virus detection techniques, with the special focus on smartphone‐based viral diagnostics whose advances have enabled laboratory‐based molecular detections to be performed with plug‐and‐play stand‐alone devices.
Meng Xiao, Feng Tian, Xin Liu, Qiaoqiao Zhou, Jiangfei Pan, Zhaofan Luo, Mo Yang, Changqing Yi   +7 more
wiley   +1 more source

Vesicular Release of Ebola Virus Matrix Protein VP40

Virology, 2001
We have analysed the expression and cellular localisation of the matrix protein VP40 from Ebola virus. Full-length VP40 and an N-terminal truncated construct missing the first 31 residues [VP40(31-326)] both locate to the plasma membrane of 293T cells when expressed transiently, while a C-terminal truncation of residues 213 to 326 [VP40(31-212)] shows ...
Timmins, Joanna, Scianimanico, Sandra, Schoehn, Guy, Weissenhorn, Winfried   +3 more
openaire   +2 more sources

Crystal structure of the matrix protein VP40 from Ebola virus [PDF]

The EMBO Journal, 2000
Ebola virus maturation occurs at the plasma membrane of infected cells and involves the clustering of the viral matrix protein VP40 at the assembly site as well as its interaction with the lipid bilayer. Here we report the X-ray crystal structure of VP40 from Ebola virus at 2.0 A resolution.
A, Dessen, V, Volchkov, O, Dolnik, H D, Klenk, W, Weissenhorn   +4 more
openaire   +2 more sources