Results 41 to 50 of about 2,213 (186)

Association of Ebola Virus Matrix Protein VP40 with Microtubules [PDF]

Journal of Virology, 2005
ABSTRACT Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for many viruses. A variety of viral proteins have been identified that interact with microtubules, either directly or via a microtubule ...
George Kallstrom, Melodi P. Javid, Tam Luong Nguyen, Gordon Ruthel, John H. Carra, M. Javad Aman, Rowena D Schokman, Timothy Nelle, Shirin S. Badie, Amy B. Will, Sina Bavari, Gretchen L. Demmin   +11 more
openaire   +3 more sources

Immunogenic and Protective Features of the Recombinant Vaccinia Virus Strain Expressing Cassette of Genes of Marburg Virus Structural Proteins

Проблемы особо опасных инфекций, 2022
The aim of the study was to create a highly immunogenic vaccine construct based on a recombinant variant of a replication-defective MVA strain of vaccinia virus, expressing virus-like particles that mimic natural infection with Marburg virus.
A. V. Semenova, G. F. Sivolobova, A. A. Grazhdantseva, S. A. P’yankov, I. S. Shul’gina, O. S. Taranov, O. V. P’yankov, D. V. Antonets, L. I. Karpenko, E. V. Starostina, M. V. Borgoyakova, A. N. Chikaev, E. V. Gavrilova, R. A. Maksyutov, G. V. Kochneva   +14 more
doaj   +1 more source

A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein [PDF]

, 2012
Conventional assays of viral particle assembly and release are time consuming and laborious. We have developed an enzymatic virus-like particle (VLP) genesis assay that rapid and quantitative and is also versatile and applicable to diverse viruses ...
Capul, Fitzpatrick, Gomis-Ruth, Gonzalez, Gottlinger, Hammonds, Hartlieb, Hatziioannou, Jasenosky, Jochmans, Jouvenet, Kaletsky, Kutluay, Martin-Serrano, Martin-Serrano, McCarthy, Morita, Neil, Neil, Paul D. Bieniasz, Perez-Caballero, Perez-Caballero, Sakuma, Sakuragi, Sam J. Wilson, Scianimanico, Shalini S. Yadav, Tang, Timmins, Van Damme, Zhou   +30 more
core   +1 more source

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Advanced Science, Volume 9, Issue 17, June 13, 2022., 2022
This review summarizes the latest development of virus detection techniques, with the special focus on smartphone‐based viral diagnostics whose advances have enabled laboratory‐based molecular detections to be performed with plug‐and‐play stand‐alone devices.
Meng Xiao, Feng Tian, Xin Liu, Qiaoqiao Zhou, Jiangfei Pan, Zhaofan Luo, Mo Yang, Changqing Yi   +7 more
wiley   +1 more source

Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Responses in Mice

Frontiers in Microbiology, 2018
Ebola virus (EBOV) causes severe hemorrhagic fevers in humans, and no approved therapeutics or vaccine is currently available. Glycoprotein (GP) is the major protective antigen of EBOV, and can generate virus-like particles (VLPs) by co-expression with ...
Shoufeng Ren, Qimei Wei, Qimei Wei, Liya Cai, Liya Cai, Xuejing Yang, Cuicui Xing, Feng Tan, Feng Tan, Jianmei W. Leavenworth, Jianmei W. Leavenworth, Shaohui Liang, Shaohui Liang, Wenquan Liu, Wenquan Liu   +14 more
doaj   +1 more source

SUMOylation in Viral Replication and Antiviral Defense

Advanced Science, Volume 9, Issue 7, March 4, 2022., 2022
This review systematically summarizes the role and mechanisms of SUMOylation in regulating viral replication and antiviral defense. SUMOylation of viral proteins, the effect of viruses on the SUMO pathway, and SUMOylation of antiviral immunity components are concluded.
Yao Fan, Xiang Li, Lei Zhang, Zhi Zong, Fangwei Wang, Jun Huang, Linghui Zeng, Chong Zhang, Haiyan Yan, Long Zhang, Fangfang Zhou   +10 more
wiley   +1 more source

Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak [PDF]

, 2015
The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to ...
Jiang, Xiaowei, Lovell, Simon C., Olabode, Abayomi S., Robertson, David L.   +3 more
core   +1 more source

Escaping the Lion’s Den: redirecting autophagy for unconventional release and spread of viruses

The FEBS Journal, Volume 288, Issue 13, Page 3913-3927, July 2021., 2021
RNA virus progenies undergo secretion and spread via multiple pathways. We highlight recent evidence on the autophagosome‐derived unconventional route. The inner membrane of these organelles can either disintegrate to release free virions or stay intact to release populations of virions in membrane‐bound forms, which are then internalized into ...
Qi Wen Teo, Sophie Wilhelmina van Leur, Sumana Sanyal   +2 more
wiley   +1 more source

Oligomerization and polymerization of the filovirus matrix protein VP40

Virology, 2003
The matrix protein VP40 from Ebola virus plays an important role in the assembly process of virus particles by interacting with cellular factors, cellular membranes, and the ribonuclearprotein particle complex. Here we show that the N-terminal domain of VP40 folds into a mixture of two different oligomeric states in vitro, namely hexameric and ...
Guy Schoehn, Rob W.H. Ruigrok, Winfried Weissenhorn, Hans-Dieter Klenk, Joanna Timmins, Christine Kohlhaas   +5 more
openaire   +3 more sources

The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress [PDF]

, 2016
VP40 is one of eight proteins encoded by the Ebola Virus (EBOV) and serves as the primary matrix protein, forming virus like particles (VLPs) from mammalian cells without the need for other EBOV proteins.
Johnson, Kristen A., Scott, Jordan L., Stahelin, Robert V., Taghon, Geoffrey J. F.   +3 more
core   +1 more source