Results 51 to 60 of about 2,832 (180)
Проблемы особо опасных инфекций, 2022 The aim of the study was to create a highly immunogenic vaccine construct based on a recombinant variant of a replication-defective MVA strain of vaccinia virus, expressing virus-like particles that mimic natural infection with Marburg virus.
A. V. Semenova +14 more
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Membrane Penetrating Ability of Ebola Matrix Protein, VP40 [PDF]
Biophysical Journal, 2013 Ebola from the filoviridae family of viruses causes severe and mostly fatal hemorrhagic fevers in primates and has been listed as a category IV pathogen by the NIH. Viral Protein 40 (VP40), the major matrix protein of Ebola virus, regulates the assembly and budding of the virus and alone harbors the ability to form virus-like particles (VLPs) from ...
Soni, Smita P. +3 more
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Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology
Virology Journal, 2006 Recently we described a role for Ebola virus proteins, NP, GP, and VP35 in enhancement of VP40 VLP budding. To explore the possibility that VLP structure was altered by co-expression of EBOV proteins leading to the observed enhancement of VP40 VLP ...
Harty Ronald N +2 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Monoclonal antibodies (mAbs) are presently the most promising treatment against Ebola virus disease (EVD), and cocktail of two or more antibodies likely confers protection through complementary mechanisms.
Dong-Shan Yu +10 more
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Obtaining Recombinant Antigens for the Development of Serological Diagnosis of Marburg Fever
Проблемы особо опасных инфекций, 2021 Aim. Production of recombinant viral antigens of the main immunodominant proteins: glycoprotein (GPΔMLD), nucleoprotein (NP) and matrix protein (VP40) of the Marburg virus, as well as the study of their antigenic and immunogenic properties.Materials and ...
N. V. Volkova +6 more
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The VP35 and VP40 proteins of filoviruses [PDF]
FEBS Letters, 1993 The fragments of genomic RNA sequences of Marburg (MBG) and Ebola (EBO) viruses are reported. These fragments were found to encode the VP35 and VP40 proteins. The canonic sequences were revealed before and after each open reading frame. It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA ...
Bukreyev, A.A. +3 more
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Analysis of the multifunctionality of Marburg virus VP40
Journal of General Virology, 2018 The Marburg virus (MARV) matrix protein, VP40, is a multifunctional protein that is essential for the assembly and release of viral particles, inhibition of the interferon response and viral transcription/replication. VP40 is assumed to be present as soluble monomers and membrane-bound higher-order oligomers.
Alexander, Koehler +3 more
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The Lancet Microbe, 2021 Summary: Background: Insufficient long-term data are available on antibody kinetics in survivors of Ebola virus disease (EVD). Likewise, few studies, with very small sample sizes, have investigated cross-reactions between Ebolavirus spp.
Mamadou Saliou Kalifa Diallo, MSc +58 more
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Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles [PDF]
The Journal of Infectious Diseases, 2018 Ebola virus (EBOV) mainly targets myeloid cells; however, extensive death of T cells is often observed in lethal infections. We have previously shown that EBOV VP40 in exosomes causes recipient immune cell death.Using VP40-producing clones, we analyzed donor cell cycle, extracellular vesicle (EV) biogenesis, and recipient immune cell death ...
Pleet, Michelle L +14 more
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Informatics in Medicine Unlocked, 2021 Bombali Ebolavirus belongs to the RNA group of viruses which causes lethal hemorrhagic fever with a high mortality rate. Despite these facts, yet there is no approved vaccine have been developed for the eradication of Bombali Ebolavirus infections ...
Mujahed I. Mustafa +3 more
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