Results 51 to 60 of about 2,213 (186)
Journal of Clinical Laboratory Analysis, Volume 35, Issue 6, June 2021., 2021 Marburg virus (MARV) and Ebola virus (EBOV) are acute infections with high case fatality rates. It is great significance for epidemic monitoring and prevention and control of infectious diseases by development of a rapid, specific and sensitive quantitative PCR method to detect two pathogens simultaneously.
Zhikang Yu +3 more
wiley +1 more source
Analysis of the multifunctionality of Marburg virus VP40
Journal of General Virology, 2018 The Marburg virus (MARV) matrix protein, VP40, is a multifunctional protein that is essential for the assembly and release of viral particles, inhibition of the interferon response and viral transcription/replication. VP40 is assumed to be present as soluble monomers and membrane-bound higher-order oligomers.
Stephan Becker +3 more
openaire +3 more sources
Obtaining Recombinant Antigens for the Development of Serological Diagnosis of Marburg Fever
Проблемы особо опасных инфекций, 2021 Aim. Production of recombinant viral antigens of the main immunodominant proteins: glycoprotein (GPΔMLD), nucleoprotein (NP) and matrix protein (VP40) of the Marburg virus, as well as the study of their antigenic and immunogenic properties.Materials and ...
N. V. Volkova +6 more
doaj +1 more source
Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer [PDF]
, 2017 Filovirus infections cause hemorrhagic fever in humans and non-human primates that often results in high fatality rates. The Marburg virus is a lipid-enveloped virus from the Filoviridae family and is closely related to the Ebola virus.
Bhattarai, Nisha +4 more
core +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Monoclonal antibodies (mAbs) are presently the most promising treatment against Ebola virus disease (EVD), and cocktail of two or more antibodies likely confers protection through complementary mechanisms.
Dong-Shan Yu +10 more
doaj +1 more source
Data from: A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection [PDF]
, 2017 The dataset contains findings and information from 51 seroprevelance studies performed from on samples collected from 1961 to 2016. These investigated 84 exposure-defined subgroups of subjects reported to have had no symptoms of EVD during the outbreak ...
Bower, Hilary, Glynn, Judith
core +2 more sources
Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles [PDF]
The Journal of Infectious Diseases, 2018 Ebola virus (EBOV) mainly targets myeloid cells; however, extensive death of T cells is often observed in lethal infections. We have previously shown that EBOV VP40 in exosomes causes recipient immune cell death.Using VP40-producing clones, we analyzed donor cell cycle, extracellular vesicle (EV) biogenesis, and recipient immune cell death ...
Fatah Kashanchi +14 more
openaire +3 more sources
Charakterisierung der Rolle des endosomalen Recycling-Systems für den intrazellulären Transport des Marburg Virus Glykoproteins [PDF]
, 2019 Das Marburg Virus (MARV), das zur Familie der Filoviridae gezählt wird, ist ein Erreger schwerer Fieber mit Letalitätsraten von bis zu 90 %. Das Glykoprotein GP stellt das einzige Oberflächenprotein des MARV dar und daher ist sein korrekter Transport zu ...
Halwe, Sandro
core +1 more source
Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors
International Journal of Molecular Sciences, 2023 The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in primates. However, there are no regulatorily approved drugs against the Ebola virus disease (EVD). The highly virulent and lethal nature of EVD highlights the need to develop therapeutic agents.
Emmanuel Broni +8 more
openaire +2 more sources
Virtual screening of the inhibitors targeting at the viral protein 40 of Ebola virus [PDF]
, 2016 Multilingual abstracts in the six official working languages of the United Nations.
Aiping Lu +7 more
core +2 more sources