Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies [PDF]
, 2006 Recombinant baculoviruses (rBV) expressing Ebola virus VP40 (rBV-VP40) or GP (rBV-GP) proteins were generated. Infection of Sf9 insect cells by rBV-VP40 led to assembly and budding of filamentous particles from the cell surface as shown by electron ...
Bennouna, Soumaya +9 more
core +1 more source
Monitoring peripheral protein oligomerization on biological membranes [PDF]
, 2013 Peripheral proteins transiently interact with cellular membranes where they regulate important cellular events such as signal transduction. A number of peripheral proteins harbor lipid-binding modules that not only bind selectively with nanomolar ...
Adu-Gyamfi +33 more
core +1 more source
Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]
, 2014 Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin +11 more
core +2 more sources
Functional characterization of Ebola virus L-domains using VSV recombinants [PDF]
, 2005 VSV recombinants containing the overlapping L-domain sequences from Ebola virus VP40 (PTAPPEY) were recovered by reverse-genetics. Replication kinetics of M40-WT, M40-P24L, and M40-Y30A were indistinguishable from VSV-WT in BHK-21 cells, whereas the ...
Harty, Ronald N. +2 more
core +1 more source
Die IRE1-abhängige ER-Stress-Antwort wird durch antagonistische Effekte der Marburg Virus Proteine GP und VP30 ausbalanciert [PDF]
, 2019 Das Marburg Virus (MARV) gehört, wie das Ebola Virus (EBOV), zur Familie der Filoviridae. Im Menschen führt eine Infektion mit dem MARV häufig zu schweren Fiebererkrankungen mit einer Letalitätsrate von bis zu 90%.
Rohde, Cornelius
core +1 more source
TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine [PDF]
, 2013 Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue ...
Ahmed, Asim Aminsharif +11 more
core +3 more sources
Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses. [PDF]
, 2017 Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune ...
Agrati +54 more
core +4 more sources
Viruses, 2020 Ebola virus infections lead to severe hemorrhagic fevers in humans and nonhuman primates; and human fatality rates are as high as 67%−90%. Since the Ebola virus was discovered in 1976, the only available treatments have been medical support or the ...
Fangfang Wu +13 more
doaj +1 more source
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors. [PDF]
, 2016 Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood.
Cose, Stephen +14 more
core +2 more sources
Marketing Strategies in Nanomaterials for Sensor Applications: Bridging Lab to Market
Global Challenges, Volume 9, Issue 5, May 2025.This work discusses strategies for the successful commercialization of nanomaterial‐based sensors, including regulatory compliance and industry collaboration. It highlights unique value propositions, intellectual property protection, and customer education to enhance market acceptance.
Anoop Singh +9 more
wiley +1 more source