Results 61 to 70 of about 2,832 (180)

Oligomerization and polymerization of the filovirus matrix protein VP40

Virology, 2003
The matrix protein VP40 from Ebola virus plays an important role in the assembly process of virus particles by interacting with cellular factors, cellular membranes, and the ribonuclearprotein particle complex. Here we show that the N-terminal domain of VP40 folds into a mixture of two different oligomeric states in vitro, namely hexameric and ...
Timmins, Joanna, Schoehn, Guy, Kohlhaas, Christine, Klenk, Hans-Dieter, Ruigrok, Rob W.H, Weissenhorn, Winfríed   +5 more
openaire   +2 more sources

High-resolution Crystal Structure of Dimeric VP40 FromSudan ebolavirus [PDF]

Journal of Infectious Diseases, 2015
Ebolaviruses cause severe hemorrhagic fever. Central to the Ebola life cycle is the matrix protein VP40, which oligomerizes and drives viral budding. Here we present the crystal structure of the Sudan virus (SUDV) matrix protein. This structure is higher resolution (1.6 Å) than previously achievable.
Matthew C, Clifton, Jessica F, Bruhn, Kateri, Atkins, Terry L, Webb, Ruth O, Baydo, Amy, Raymond, Donald D, Lorimer, Thomas E, Edwards, Peter J, Myler, Erica Ollmann, Saphire   +9 more
openaire   +2 more sources

Packaging of actin into Ebola virus VLPs

Virology Journal, 2005
The actin cytoskeleton has been implicated in playing an important role assembly and budding of several RNA virus families including retroviruses and paramyxoviruses.
Harty Ronald N, Han Ziying
doaj   +1 more source

PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding

Journal of Lipid Research
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in ...
Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin   +8 more
doaj   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley   +1 more source

Marburg Virus VP40 Antagonizes Interferon Signaling in a Species-Specific Manner [PDF]

Journal of Virology, 2011
ABSTRACT Marburgviruses are zoonotic pathogens that cause lethal hemorrhagic fever in humans and nonhuman primates. However, they do not cause lethal disease in immunocompetent mice unless they are adapted to this species.
Charalampos, Valmas, Christopher F, Basler   +1 more
openaire   +2 more sources

A Chimeric Sudan Virus-Like Particle Vaccine Candidate Produced by a Recombinant Baculovirus System Induces Specific Immune Responses in Mice and Horses

Viruses, 2020
Ebola virus infections lead to severe hemorrhagic fevers in humans and nonhuman primates; and human fatality rates are as high as 67%−90%. Since the Ebola virus was discovered in 1976, the only available treatments have been medical support or the ...
Fangfang Wu, Shengnan Zhang, Ying Zhang, Ruo Mo, Feihu Yan, Hualei Wang, Gary Wong, Hang Chi, Tiecheng Wang, Na Feng, Yuwei Gao, Xianzhu Xia, Yongkun Zhao, Songtao Yang   +13 more
doaj   +1 more source

Exploring 2D Graphene‐Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective

Small Science, Volume 5, Issue 6, June 2025.
Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos, Nevena Todorova, Irene Yarovsky   +2 more
wiley   +1 more source

Molecular docking based screening of compounds against VP40 from Ebola virus [PDF]

Bioinformation, 2016
يسبب فيروس الإيبولا حمى نزفية شديدة ومميتة في كثير من الأحيان لدى البشر. أثر وباء الإيبولا لعام 2014 على العديد من البلدان. يلعب بروتين مصفوفة الفيروس (VP40) دورًا مركزيًا في تجميع الفيروسات وتبرعمها. نظرًا لعدم وجود لقاح أو دواء معتمد من إدارة الأغذية والعقاقير (FDA) ضد العدوى الفيروسية بالإيبولا، يلزم اكتشاف مركبات جديدة ذات أنماط ربط مختلفة ضدها ...
Hanaa M Alam El-Din, Samah A. Loutfy, Nasra Fathy, Mostafa H. Elberry, Ahmed Mahmoud Mayla, Sara Kassem, Asif Naqvi   +6 more
openaire   +2 more sources