Results 71 to 80 of about 2,213 (186)

Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]

, 2018
Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G., Hagen, Katie R., Holbrook, Michael R., Huzella, Louis M., Jahrling, Peter B., Johnson, Reed F., Perry, Donna L., Schnell, Matthias J.   +7 more
core   +1 more source

Marburg Virus Disease: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
wiley   +1 more source

MONOCLONAL ANTIBODIES AND RECOMBINANT PROTEINS OF FILOVIRUSES: IMMUNOCHEMICAL PROPERTIES AND EVALUATION OF THEIR EFFICIENCY FOR IMMUNE DIAGNOSTICS OF MARBURG AND EBOLA VIRUSES

Медицинская иммунология, 2014
A panel of monoclonal antibodies (MAbs) against VP35, VP40 and NP viral proteins of Marburg and Ebola viruses, as well as recombinant VP35, VP40 and NP proteins were generated and tested for their capacity to specific immune reactions.
E. I. Kazachinskaia, A. V. Ivanova, A. V. Sorokin, E. L. Subbotina, A. V. Kachko, I. A. Razumov, V. B. Loktev   +6 more
doaj   +1 more source

Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression. [PDF]

PLoS Neglected Tropical Diseases, 2011
Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis.
Victoria Wahl-Jensen, Sabine Kurz, Friedericke Feldmann, Lukas K Buehler, Jason Kindrachuk, Victor DeFilippis, Jean da Silva Correia, Klaus Früh, Jens H Kuhn, Dennis R Burton, Heinz Feldmann   +10 more
doaj   +1 more source

Effect of platelet‐rich plasma and platelet‐rich fibrin on healing of burn wound with dual‐species biofilm

The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 3, March 2025.
Abstract This study evaluated the impact of platelet‐rich plasma (PRP) and platelet‐rich fibrin (PRF) on burn wound with dual‐species biofilm. Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus) were applied to infect the burn wound in rats to establish a dual‐species biofilm model.
Wen‐Dan Li, Fang Lin, Yu Sun, Zi‐Jing Zhu, Mei‐Liang Luo, Yi‐Qi Zeng, Zhen Lin, Mou Zhou   +7 more
wiley   +1 more source

Molecular docking study of anti-viral FDA-approved drugs as novel entry and replication Ebola viral inhibitors [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: Because of the reported high ability of virulence and the lack of appropriate drug of Ebola virus during the last decades, many investigations have been accomplished regarding discovery and the introduction of anti-Ebola drugs ...
Saghi Sepehri, Vahed Adhami
doaj  

Marburg virus evades interferon responses by a mechanism distinct from ebola virus.

PLoS Pathogens, 2010
Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-alpha/beta signaling but utilize different mechanisms. EBOV inhibits IFN signaling via its VP24 protein which blocks the nuclear accumulation
Charalampos Valmas, Melanie N Grosch, Michael Schümann, Judith Olejnik, Osvaldo Martinez, Sonja M Best, Verena Krähling, Christopher F Basler, Elke Mühlberger   +8 more
doaj   +1 more source

Ebola virus protein VP40 stimulates IL-12– and IL-18–dependent activation of human natural killer cells

JCI Insight, 2022
Accumulation of activated natural killer (NK) cells in tissues during Ebola virus infection contributes to Ebola virus disease (EVD) pathogenesis. Yet, immunization with Ebola virus-like particles (VLPs) comprising glycoprotein and matrix protein VP40 ...
Hung Le, Paul Spearman, Stephen N. Waggoner, Karnail Singh   +3 more
doaj   +1 more source

Identifizierung und Charakterisierung der Interaktion von Marburg-Virus VP30 mit den zellulären Proteinen PIAS1, PIAS2 und SETDB1 [PDF]

, 2018
Marburg-Virus (MARV) und Ebola-Virus (EBOV), Mitglieder der Virusfamilie der Filoviridae, lösen schwere, oft tödlich verlaufende Erkrankungen im Menschen und nicht-menschlichen Primaten aus.
Klüver, Michael
core   +1 more source

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source