Results 81 to 90 of about 2,832 (180)

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Ebolavirus evolution and emergence are associated with land use change

Ecological Monographs, Volume 95, Issue 1, February 2025.
Abstract Anthropogenic land use change facilitates disease emergence by altering the interface between humans and pathogen reservoirs and is hypothesized to drive pathogen evolution. Here, we show a positive association between land use change and the evolution and dispersal of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV).
Christian E. Lange, Thomas R. Barnum, David J. McIver, Matthew LeBreton, Karen Saylors, Charles Kumakamba, Sara Lowes, Eduardo Montero, Robert L. Cohen   +8 more
wiley   +1 more source

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding [PDF]

Journal of Virology, 2016
ABSTRACT Ebola virus (EBOV) and Marburg virus (MARV) belong to the Filoviridae family and can cause outbreaks of severe hemorrhagic fever, with high mortality rates in humans. The EBOV VP40 (eVP40) and MARV VP40 (mVP40) matrix proteins play a central role in virion assembly and egress, such that ...
Han, Z, Sagum, C.A, Bedford, M.T, Sidhu, S.S, Sudol, M, Harty, R.N   +5 more
openaire   +2 more sources

A coevolution analysis for identifying protein-protein interactions by Fourier transform. [PDF]

PLoS ONE, 2017
Protein-protein interactions (PPIs) play key roles in life processes, such as signal transduction, transcription regulations, and immune response, etc. Identification of PPIs enables better understanding of the functional networks within a cell.
Changchuan Yin, Stephen S-T Yau
doaj   +1 more source

Can Marburg virus be sexually transmitted?

Health Science Reports, Volume 7, Issue 8, August 2024.
Abstract Background and Aim Marburg virus (MARV) is a highly virulent virus of animal origin and the cause of a lethal infection (known as Marburg virus disease [MVD]) with a case‐fatality ratio ranging from 24% to 90%. While the potential nonzoonotic routes of virus spread are plausible, the risk is not yet fully determined.
Hassan Karami, Arash Letafati, Somayeh Sadat Hosseini Fakhr   +2 more
wiley   +1 more source

Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Extracellular vesicles (EVs) are emerging as promising carriers for the delivery of therapeutic biologics. Genetic engineering represents a robust strategy for loading proteins of interest into EVs. Identification of EV‐enriched proteins facilitates protein cargo loading efficiency.
Rui Chen, Ziqin Kang, Wenhao Li, Tianshu Xu, Yongqiang Wang, Qiming Jiang, Yuepeng Wang, Zixian Huang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

In-silico Structural and Molecular Docking-Based Drug Discovery Against Viral Protein (VP40) of Marburg Virus: A Causative Agent of MAVD [PDF]

, 2021
Sameer Quazi, Tanya Golani, Nashat Akhta, Christina Thomas, Z Haider   +4 more
openalex   +1 more source

Mapping of the VP40-Binding Regions of the Nucleoprotein of Ebola Virus [PDF]

Journal of Virology, 2007
ABSTRACT Expression of Ebola virus nucleoprotein (NP) in mammalian cells leads to the formation of helical structures, which serve as a scaffold for the nucleocapsid. We recently found that NP binding with the matrix protein VP40 is important for nucleocapsid incorporation into virions (T. Noda, H. Ebihara, Y. Muramoto, K. Fujii, A. Takada, H.
Takeshi, Noda, Shinji, Watanabe, Hiroshi, Sagara, Yoshihiro, Kawaoka   +3 more
openaire   +2 more sources

Identification of continuous human B-cell epitopes in the VP35, VP40, nucleoprotein and glycoprotein of Ebola virus. [PDF]

PLoS ONE, 2014
Ebola virus (EBOV) is a highly virulent human pathogen. Recovery of infected patients is associated with efficient EBOV-specific immunoglobulin G (IgG) responses, whereas fatal outcome is associated with defective humoral immunity.
Pierre Becquart, Tanel Mahlakõiv, Dieudonné Nkoghe, Eric M Leroy   +3 more
doaj   +1 more source

Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice

Microorganisms, 2020
Kunjin virus (KUNV) is an attenuated strain of the severe neurotropic West Nile virus (WNV). The virus has a single-strand positive-sense RNA genome that encodes a polyprotein.
Pham-Tue-Hung Tran, Naveed Asghar, Urban Höglund, Olivia Larsson, Lars Haag, Ali Mirazimi, Magnus Johansson, Wessam Melik   +7 more
doaj   +1 more source