Results 81 to 90 of about 2,213 (186)

Ebolavirus evolution and emergence are associated with land use change

Ecological Monographs, Volume 95, Issue 1, February 2025.
Abstract Anthropogenic land use change facilitates disease emergence by altering the interface between humans and pathogen reservoirs and is hypothesized to drive pathogen evolution. Here, we show a positive association between land use change and the evolution and dispersal of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV).
Christian E. Lange, Thomas R. Barnum, David J. McIver, Matthew LeBreton, Karen Saylors, Charles Kumakamba, Sara Lowes, Eduardo Montero, Robert L. Cohen   +8 more
wiley   +1 more source

Lipid binding properties of Ebola virus matrix protein VP40

The FASEB Journal, 2013
The Ebola virus (EBOV) is a pathogen that causes hemorrhagic fevers in humans. It is most prevalent in Africa, where outbreaks with fatality rates of up to 90% have occurred. It also poses a global threat as infections can be spread rapidly. While it is known that EBOV infections function by inhibiting the immune system, the specific cellular secretion
Robert V. Stahelin, Jordan L. Scott, Sylvia S. Yong   +2 more
openaire   +1 more source

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Viruses, 2020
Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host ...
Kaveesha J. Wijesinghe, Luke McVeigh, Monica L. Husby, Nisha Bhattarai, Jia Ma, Bernard S. Gerstman, Prem P. Chapagain, Robert V. Stahelin   +7 more
doaj   +1 more source

Cell–cell contact promotes Ebola virus GP-mediated infection [PDF]

, 2016
Ebola virus (EBOV) is a highly pathogenic filovirus that causes hemorrhagic fever in humans and animals. Here we provide evidence that cell–cell contact promotes infection mediated by the glycoprotein (GP) of EBOV.
Cohen, Fredric S., Li, Minghua, Liu, Shan-Lu, Miao, Chunhui, Zheng, Yi-Min   +4 more
core   +1 more source

Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals

Protein Science, Volume 34, Issue 1, January 2025.
Abstract The ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to ...
Fernando Montero, Marisa Parra‐López, Alejandro Rodríguez‐Martínez, Javier Murciano‐Calles, Pedro Buzon, Ziying Han, L.‐Y. Lin, Maria C. Ramos, Javier Ruiz‐Sanz, Jose C. Martinez, Marco Radi, Christiane Moog, Sandra Diederich, Ronald N. Harty, Horacio Pérez‐Sánchez, Francisca Vicente, Francisco Castillo, Irene Luque   +17 more
wiley   +1 more source

A coevolution analysis for identifying protein-protein interactions by Fourier transform. [PDF]

PLoS ONE, 2017
Protein-protein interactions (PPIs) play key roles in life processes, such as signal transduction, transcription regulations, and immune response, etc. Identification of PPIs enables better understanding of the functional networks within a cell.
Changchuan Yin, Stephen S-T Yau
doaj   +1 more source

Antiviral Properties of ISG15 [PDF]

, 2010
The type I interferon system plays a critical role in limiting the spread of viral infection. Viruses induce the production of interferon (IFN), which after binding to the IFN-α/β receptor (IFNAR), and triggering of the JAK/STAT signaling cascade ...
Lenschow, Deborah J.
core   +4 more sources

Can Marburg virus be sexually transmitted?

Health Science Reports, Volume 7, Issue 8, August 2024.
Abstract Background and Aim Marburg virus (MARV) is a highly virulent virus of animal origin and the cause of a lethal infection (known as Marburg virus disease [MVD]) with a case‐fatality ratio ranging from 24% to 90%. While the potential nonzoonotic routes of virus spread are plausible, the risk is not yet fully determined.
Hassan Karami, Arash Letafati, Somayeh Sadat Hosseini Fakhr   +2 more
wiley   +1 more source

Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Extracellular vesicles (EVs) are emerging as promising carriers for the delivery of therapeutic biologics. Genetic engineering represents a robust strategy for loading proteins of interest into EVs. Identification of EV‐enriched proteins facilitates protein cargo loading efficiency.
Rui Chen, Ziqin Kang, Wenhao Li, Tianshu Xu, Yongqiang Wang, Qiming Jiang, Yuepeng Wang, Zixian Huang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress [PDF]

Journal of Virology, 2017
ABSTRACT Ebola virus (EBOV) is a member of the Filoviridae family and the cause of hemorrhagic fever outbreaks. The EBOV VP40 (eVP40) matrix protein is the main driving force for virion assembly and budding.
Sachdev S. Sidhu, Ziying Han, Fumio Takizawa, Corbett T. Berry, Bruce D. Freedman, Jing Kong, J. Oriol Sunyer, Mark T. Bedford, Gordon Ruthel, Marius Sudol, Ronald N. Harty, Cari A. Sagum   +11 more
openaire   +3 more sources