Results 81 to 90 of about 3,985 (161)

Protection of IFNAR (-/-) mice against bluetongue virus serotype 8, by heterologous (DNA/rMVA) and homologous (rMVA/rMVA) vaccination, expressing outer-capsid protein VP2.

PLoS ONE, 2013
The protective efficacy of recombinant vaccines expressing serotype 8 bluetongue virus (BTV-8) capsid proteins was tested in a mouse model. The recombinant vaccines comprised plasmid DNA or Modified Vaccinia Ankara viruses encoding BTV VP2, VP5 or VP7 ...
Tamara Kusay Jabbar, Eva Calvo-Pinilla, Francisco Mateos, Simon Gubbins, Abdelghani Bin-Tarif, Katarzyna Bachanek-Bankowska, Oya Alpar, Javier Ortego, Haru-Hisa Takamatsu, Peter Paul Clement Mertens, Javier Castillo-Olivares   +10 more
doaj   +1 more source

Transcriptome and co-expression network analyses of key genes and pathways associated with differential abscisic acid accumulation during maize seed maturation

BMC Plant Biology, 2022
Background Currently, mechanical maize kernel harvesting has not been fully utilized in developing countries including China, partly due to the absence of suitable cultivars capable of rapid desiccation during seed maturation.
Liangjie Niu, Cui Du, Wenrui Wang, Man Zhang, Wei Wang, Hui Liu, Jinghua Zhang, Xiaolin Wu   +7 more
doaj   +1 more source

Evolution and diversity of the Microviridae viral family through a collection of 81 new complete genomes assembled from virome reads. [PDF]

, 2012
International audienceRecent studies suggest that members of the Microviridae (a family of ssDNA bacteriophages) might play an important role in a broad spectrum of environments, as they were found in great number among the viral fraction from seawater ...
Debroas, Didier, Enault, François, Krupovic, Mart, Poulet, Axel, Roux, Simon   +4 more
core   +5 more sources

The effect of pH on the structure of Bluetongue virus VP5

Journal of General Virology
The unenveloped Bluetongue virus capsid comprises several structural layers, the inner two comprising a core, which assembles before addition of the outer proteins, VP2 and VP5. Two symmetric trimers of VP5 fit like pegs into two distinct pits on the core and undergo pH conformational changes in the context of the virus, associated with cell entry ...
Hanwen Zhang, Kamel El Omari, Geoff Sutton, David I. Stuart   +3 more
openaire   +3 more sources

N-Terminal Myristoylated VP5 is Required for Penetrating Cell Membrane and Promoting Infectivity in Aquareoviruses [PDF]

Virologica Sinica, 2018
Nonenveloped animal viruses must disrupt the host cell membrane to initiate infection. Although myristoylated outer capsid protein is known to be responsible for membrane penetration in nonenveloped viruses, the mechanisms underlying membrane penetration to enter the host cytoplasm remain poorly understood, compared to the membrane fusion mechanisms of
Qingxiu Chen, Hong Guo, Fuxian Zhang, Qin Fang   +3 more
openaire   +2 more sources

Formulation and evaluation of repurposed ketoconazole‐loaded transferosomal gel for enhanced trichogenic effects

Clinical and Translational Discovery, Volume 5, Issue 2, April 2025.
Development and characterization of a ketoconazole‐loaded transferosomal gel for enhanced trichogenic activity . Abstract This study was focused to formulate and optimize transferosomes encapsulating ketoconazole (KTZ) for its repurposed use as a hair growth promoting agent.
Madhvi Mishra, Gopal Thakur, Pallavi Bassi, Gurpreet Kaur, Thakur Gurjeet Singh, Narinderpal Kaur, Ling Shing Wong, Satyanarayana Reddy, Gowtham Kuppusamy, Vinoth Kumarasamy, Gaurav Gupta, Vetriselvan Subramaniyan   +11 more
wiley   +1 more source

FaNDUFB9 Attenuates Strawberry Mottle Virus Infection by Inhibiting the Activity of the Viral Gene Silencing Suppressor, Pro2Glu

Molecular Plant Pathology, Volume 26, Issue 3, March 2025.
Strawberry NADH dehydrogenase (ubiquinone) 1β subcomplex subunit 9 interacts with strawberry mottle virus Pro2Glu to reduce Pro2Glu expression, attenuating its silencing suppressor activity and affecting the viral RNA levels. ABSTRACT Strawberry mottle virus (SMoV) significantly compromises strawberry fruit quality and yield.
Tengfei Xu, Binhui Zhan, Zhixiang Zhang, Lingjiao Fan, Dehang Gao, Zhenfei Dong, Shifang Li, Hongqing Wang   +7 more
wiley   +1 more source

A Nuclear Localization Signal in Herpesvirus Protein VP1-2 Is Essential for Infection via Capsid Routing to the Nuclear Pore

, 2012
To initiate infection, herpesviruses must navigate to and transport their genomes across the nuclear pore. VP1-2 is a large structural protein of the virion that is conserved in all herpesviruses and plays multiple essential roles in virus replication ...
Abaitua, F, Bolstad, M, Crump, CM, Hollinshead, M, O'Hare, P   +4 more
core   +1 more source

Base Usage and Dinucleotide Frequency of Infectious Bursal Disease Virus [PDF]

, 2004
Base usage and dinucleotide frequency have been extensively studied in many eukaryotic organisms and bacteria, but not for viruses. In this paper, a comprehensive analysis of these aspects for infectious bursal disease virus (IBDV) was presented.
Bejo, Mohd Hair, Goh, Yong Meng, Ideris, Aini, Omar, Abdul Rahman, Tan, Do Yew   +4 more
core   +1 more source

Epicutaneous immunotherapy for the treatment of peanut allergy

Allergy, Volume 80, Issue 1, Page 63-76, January 2025.
Abstract Peanut allergy treatment options remain limited, but novel approaches are being studied, including epicutaneous immunotherapy (EPIT). EPIT uses the cutaneous immune system to promote tolerance to food allergens. Viaskin™ Peanut, an approach to EPIT in late‐stage clinical development uses an occlusive patch with a condensation chamber that ...
Mayuran Ravindran, Hugh A. Sampson, Edwin H. Kim, Katharine J. Bee, Todd D. Green, A. Wesley Burks   +5 more
wiley   +1 more source