Results 1 to 10 of about 1,561 (108)

PACAP regulates VPAC1 expression, inflammatory processes and lipid homeostasis in M1- and M2-macrophages [PDF]

Frontiers in Cardiovascular Medicine, 2023
BackgroundPituitary adenylate cyclase-activating polypeptide (PACAP) acts as an anti-atherogenic neuropeptide and plays an important role in cytoprotective, as well as inflammatory processes, and cardiovascular regulation.
Roman Witzel, Annika Block, Solvey Pollmann, Leandra Oetzel, Fenja Fleck, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz   +7 more
doaj   +2 more sources

VPAC1 and VPAC2 Receptor Heterozygosity Confers Distinct Biological Properties to BV2 Microglial Cells [PDF]

Cells
Microglial cells, the resident immune cells of the central nervous system (CNS), are essential for maintaining CNS homeostasis. Dysregulation of microglial function is implicated in the pathogenesis of various neurodegenerative diseases.
Xin Ying Rachel Song, Margo Iris Jansen, Rubina Marzagalli, Giuseppe Musumeci, Velia D’Agata, Alessandro Castorina   +5 more
doaj   +2 more sources

Development and pharmacological characterization of novel multi- calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide receptor antagonists. [PDF]

Headache
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Tasma Z, Siow A, Harris PWR, Brimble MA, Hay DL, Walker CS.   +5 more
europepmc   +2 more sources

Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide [PDF]

Frontiers in Molecular Neuroscience, 2023
IntroductionPituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on
Zala Slabe, Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevenšek, Dick F. Swaab, Dick F. Swaab   +6 more
doaj   +2 more sources

VPAC receptor positivity in comparison with mp-MRI in the diagnosis of prostate cancer: A preliminary study. [PDF]

BJUI Compass
Abstract Objective The study aimed to prospectively evaluate the feasibility of diagnosing PCa using voided urine samples and by targeting the genomic VPAC (vasoactive intestinal peptide and pituitary adenylate cyclase‐activating peptide) receptors in comparison with multiparametric magnetic resonance imaging (mp‐MRI) in male patients (≥40 years of age)
Setya N, Ghagane SC, Nerli RB, Bokare A, Thakur ML, Gomella L.   +5 more
europepmc   +2 more sources

VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model [PDF]

The Journal of Headache and Pain
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target.
Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen   +13 more
doaj   +2 more sources

CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide [PDF]

Life
Migraines are a frequently occurring neurological condition that affects up to 16% of the global population. The precise pathomechanism of the disease remains unknown, but from animal and human observations, it appears that calcium/calmodulin-dependent ...
Gábor Nagy-Grócz, Eleonóra Spekker, Tamás Körtési, Klaudia Flóra Laborc, Zsuzsanna Bohár, Annamária Fejes-Szabó, László Vécsei, Árpád Párdutz   +7 more
doaj   +2 more sources

Rhinologic Conditions of Pregnancy: A Retrospective Cohort Study. [PDF]

OTO Open
Abstract Objective To better understand the prevalence, risk factors, and management strategies of pregnancy‐related rhinologic conditions. Study Design Retrospective cohort study from January 2013 to January 2023. Setting Tertiary level Otolaryngology–Head and Neck Surgery clinic. Methods Pregnant patients with rhinologic concerns were included.
Eltawil Y, Callander JK, Loftus PA.
europepmc   +2 more sources

Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells. [PDF]

Biofactors
Vasoactive intestinal peptide (VIP) acts as a promoter of human osteogenesis, enhancing the expression of early osteoblast markers and favoring both bone matrix formation and proper cytoskeletal reorganization. Moreover, VIP could be exerting a direct modulatory role on the osteoblast to osteoclast signaling by downregulating the receptor activator of ...
Castro-Vázquez D, Arribas-Castaño P, García-López I, Gutiérrez-Cañas I, Pérez-García S, Lamana A, Villanueva-Romero R, Cabrera-Martín A, Tecza K, Martínez C, Juarranz Y, Gomariz RP, Carrión M.   +12 more
europepmc   +2 more sources

Genome-Wide Translatome Analysis Following Low-Dose Ketamine to Reveal Novel Targets for Antidepressant Treatment. [PDF]

Synapse
ABSTRACT Low‐dose ketamine is an efficacious antidepressant for treatment‐resistant unipolar and bipolar depressed patients. Major depressive disorder patients receiving a single infusion report elevated mood within 2 h, and ketamine's antidepressant effects have been observed as long as 7 days posttreatment.
Miller OH, Grabole N, Wells I, Bellier L, Nassi JJ, Hall BJ.   +5 more
europepmc   +2 more sources