Results 141 to 150 of about 1,611 (152)

Functional expression of rat VPAC1 receptor in Saccharomyces cerevisiae.

Receptors & channels, 1999
The yeast Saccharomyces cerevisiae was examined as host for heterologous expression of the G protein-coupled VPAC1 receptor. Rat VPAC1 receptor cDNA and two chimeric constructs encoding the yeast mating factor pre-pro alpha-leader peptide fused in-frame to rat VPAC1 receptor were expressed in yeast cells under control of a galactose inducible promoter.
Hansen, M.K., Tams, J.W., Fahrenkrug, Jan, Pedersen, Per Amstrup   +3 more
openaire   +1 more source

Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects

Biochemical Pharmacology, 2011
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide that exerts a large array of actions in the central nervous system and periphery. Through the activation of PAC1 and VPAC1, PACAP is able to exert neuroprotective, as well as anti-inflammatory effects, two phenomena involved in the pathogenesis and the progression ...
Doan, Ngoc-Duc, Bourgault, Steve, Dejda, Agnieszka, Létourneau, Myriam, Detheux, Michel, Vaudry, David, Vaudry, Hubert, Chatenet, David, Fournier, Alain   +8 more
openaire   +3 more sources

Abstract 1485: Pilot study of VPAC1 targeted PET imaging of prostate cancer

Cancer Research, 2015
Abstract Introduction: Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase Activating Peptide Receptor 1 (VPAC1) is over-expressed in prostate cancer (PC), representing a highly suitable target for imaging and treatment. VPAC1 expression occurs at the onset of the malignancy, before alterations of cell morphology, which may be ...
Edouard J. Trabulsi, Pradeep Kumar, Sushil Tripathi, Ruth Birbe, Peter McCue, Eric Wickstrom, Charles Intenzo, Sung Kim, Robert Den, Leonard Gomella, Mathew L. Thakur   +10 more
openaire   +1 more source

Study of agonist-dependent VPAC1 receptor phosphorylation

Biochemical Society Transactions, 2002
C. Langlet, P. Vertongen, M. Waelbroeck, P. Robberecht   +3 more
openaire   +1 more source

Preventing Epileptogenesis with Vasoactive Intestinal Peptide (VIP) VPAC1 Receptor Ligands

Mesial-temporal lobe epilepsy (MTLE) is a rare type of epilepsy, and yet one of the most prevalent types of symptomatic focal epilepsy with an unknown aetiology. In many cases it is associated with other comorbidities such as hippocampal sclerosis (HS). MTLE-HS has a high socioeconomic impact as many patients are refractory to anti-seizure drugs (ASDs)
openaire   +2 more sources

VPAC1 receptors as molecular targets in breast cancer

Neuropeptides, 2006
T.W. Moody, D.H. Coy, R.T. Jensen
openaire   +1 more source

In vivo anti-obesity effect of the agonist for receptor VPAC1.

Sheng li xue bao : [Acta physiologica Sinica], 2015
It was hypothesized that the VPAC1 agonist may exert anti-obesity functions because VPAC1 is involved in the anorexigenic effects and the anti-inflammatory function of pituitary adenylate cyclase-activating polypeptide (PACAP)/vasoactive intestinal polypeptide (VIP).
Rong-Jie, Yu, Ling, Zhang, Tian-Hong, Yi, Shan-Shan, Xie, Yun, Dai   +4 more
openaire   +1 more source

VPAC1 potent facilitator of HIV-1 infection

Inpharma Weekly, 2002
openaire   +1 more source

RAMPs interact with and modulate the signalling of VPAC1 receptors

Biochemical Society Transactions, 2002
P. M. Sexton, M. Morfis, G. Christopoulos, M. Laburthe, A. Couvineau, A. Christopoulos   +5 more
openaire   +1 more source

VIP Promotes Gastric Cancer Progression VIA the VPAC1/TRPV4/CA2+ Signaling Pathway

Gastroenterology, 2017
Bo Tang, Hui Dong, Shi-Ming Yang
openaire   +1 more source