Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function [PDF]
Frontiers in Endocrinology, 2018 Multi-membrane spanning proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are extremely difficult to purify as native proteins. Consequently, the generation of antibodies that recognize the native conformation can be challenging. By
Xavier Peyrassol +15 more
doaj +4 more sources
The VPAC1 receptor: structure and function of a class B GPCR prototype [PDF]
Frontiers in Endocrinology, 2012 The class B G protein-coupled receptors (GPCRs) represents a small sub-family encompassing 15 members, and are very promising targets for the development of drugs to treat many diseases such as chronic inflammation, neurodegeneration, diabetes, stress ...
Alain eCouvineau +4 more
doaj +3 more sources
Pituitary adenylyl cyclase-activating polypeptide modulates the stress response: the involvement of different brain areas and microglia [PDF]
Frontiers in PsychiatryStress is necessary for survival. However, chronic unnecessary stress exposure leads to cardiovascular, gastrointestinal and neuropsychiatric disorders. Thus, understanding the mechanisms involved in the initiation and maintenance of the stress response ...
Anika Singh +4 more
doaj +2 more sources
VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice.
PLoS ONE, 2019 BACKGROUND:PACAP and VIP are closely related neuropeptides with wide distribution and potent effect in the vasculature. We previously reported vasomotor activity in peripheral vasculature of male wild type (WT) and PACAP-deficient (KO) mice.
Ivan Ivic +9 more
doaj +4 more sources
Screening of a specific peptide binding to VPAC1 receptor from a phage display peptide library. [PDF]
PLoS ONE, 2013 BACKGROUND/PURPOSE: The VPAC1 receptor, a member of the vasoactive intestinal peptide receptors (VIPRs), is overexpressed in the most frequently occurring malignant tumors and plays a major role in the progression and angiogenesis of a number of ...
Bo Tang +4 more
doaj +1 more source
Gastro Hep Advances, 2022 Background and Aims: Vasoactive intestinal peptide (VIP) is a neuropeptide involved in the regulation of feeding behavior and circadian rhythms, metabolism, and immunity.
Aaron C. Ericsson +6 more
doaj +1 more source
Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors
Frontiers in Endocrinology, 2021 Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
doaj +1 more source
Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis [PDF]
British Journal of Haematology, 2010 SummaryMegakaryocytes and platelets express the stimulatory G protein (Gs)‐coupled VPAC1 receptor, for which the pituitary adenylyl cyclase‐activating peptide (PACAP) and vasoactive intestinal peptide (VIP) are agonists. The neuropeptide PACAP and VPAC1 were previously found to negatively regulate megakaryopoiesis, and inhibition of their physiological
Peeters, Karen +6 more
openaire +3 more sources
The expression of vasoactive intestinal peptide receptor 1 is negatively modulated by microRNA 525-5p. [PDF]
PLoS ONE, 2010 BACKGROUND: The human Vasoactive Intestinal Peptide (VIP) is a neurokine with effects on the immune system where it is involved in promoting tolerance.
Elisa Cocco +5 more
doaj +1 more source
Brazilian Journal of Otorhinolaryngology, 2022 Introduction: Pregnancy rhinitis is a common sex hormone-related otorhinolaryngological disorder. There are some epidemiological and physiological studies on pregnancy rhinitis, but histopathological and biomolecular changes have not been studied ...
Burak Ulkumen +5 more
doaj +1 more source