Results 41 to 50 of about 1,611 (152)

Localization of Vasoactive Intestinal Polypeptide Receptor 1 (VPAC1) in Hypothalamic Neuroendocrine Oxytocin Neurons; A Potential Role in Circadian Prolactin Secretion

Frontiers in Neuroanatomy, 2020
Prolactin (PRL) is a versatile hormone and serves a broad variety of physiological functions besides lactation. The release of PRL from lactotrophs in the pituitary has in rodents been shown to be released with a circadian pattern depending on the ...
Ida Stangerup, Jens Hannibal
doaj   +1 more source

Synthesis and In Vitro Characterization of Glycopeptide Drug Candidates Related to PACAP_1–23

Molecules, 2021
The search for efficacious treatment of neurodegenerative and progressive neuroinflammatory diseases continues, as current therapies are unable to halt or reverse disease progression.
Christopher R. Apostol, Parthasaradhireddy Tanguturi, Lajos Z. Szabò, Daniel Varela, Thiago Gilmartin, John M. Streicher, Robin Polt   +6 more
doaj   +1 more source

PACAP key interactions with PAC1, VPAC1, and VPAC2 identified by molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics, 2023
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) belongs to the glucagon/secretin family. PACAP interacts with the pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) and vasoactive intestinal peptide receptors 1 and 2 (VPAC1 and VPAC2), exhibiting functions in the immune, endocrine, and nervous systems.
Fernando Augusto T. P. Meireles, Deborah Antunes, Jairo R. Temerozo, Dumith Chequer Bou-Habib, Ernesto Raul Caffarena   +4 more
openaire   +2 more sources

VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy

Frontiers in Cellular Neuroscience, 2020
Vasoactive intestinal peptide (VIP) is an important modulatory peptide throughout the CNS acting as a neurotransmitter, neurotrophic or neuroprotective factor.
Diana Cunha-Reis, Diana Cunha-Reis, Ana Caulino-Rocha, Ana Caulino-Rocha   +3 more
doaj   +1 more source

VPAC1 receptor expression in peripheral blood mononuclear cells in a human endotoxemia model [PDF]

Journal of Translational Medicine, 2013
AbstractBackgroundVasoactive intestinal peptide (VIP) exerts immune-modulatory actions mainly via VPAC1 receptor stimulation. VPAC1 may be a treatment target of inflammatory diseases, but little is known about the receptor expression profile in immune-competent cellsin vivo.Material and methods20 male healthy subjects received a single intravenous ...
Storka, Angela, Burian, Bernhard, Führlinger, Gerhard, Clive, Breanna, Sun, Terri, Crevenna, Richard, Gsur, Andrea, Mosgöller, Wilhelm, Wolzt, Michael   +8 more
openaire   +2 more sources

Discovery of PACAP and its receptors in the brain

The Journal of Headache and Pain, 2018
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP.
Takahiro Hirabayashi, Tomoya Nakamachi, Seiji Shioda   +2 more
doaj   +1 more source

High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

Journal of Diabetes Research, 2016
Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on multiple processes of glucose and energy metabolism. PACAP potentiates insulin action in adipocytes and insulin release from pancreatic β-cells, thereby enhancing glucose tolerance ...
Masanori Nakata, Boyang Zhang, Yifei Yang, Takashi Okada, Norihito Shintani, Hitoshi Hashimoto, Toshihiko Yada   +6 more
doaj   +1 more source

Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity

Journal of Obesity, 2010
Background. The pituitary adenylate cyclase activating polypeptide (PACAP) may affect adipogenesis and adipose tissue formation through interaction with its G-protein-coupled receptor VPAC1. Methods.
H. Roger Lijnen, Kathleen Freson, Marc F. Hoylaerts   +2 more
doaj   +1 more source

Microencapsulated Quercetin and Bifidobacterium animalis Independently Preserve Jejunal Enteric Neurons During Colorectal Carcinogenesis

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
Our study explores the impact of colorectal carcinogenesis on jejunal neurons of the enteric nervous system (ENS), revealing significant neuronal damage. We demonstrated that treatments with microencapsulated quercetin and Bifidobacterium animalis protect enteric neuronal density, and this is reflected in improved gastrointestinal transit times.
Lucas Casagrande, Carla Cristina de Oliveira Bernardo, Sabrina Silva Sestak, Maysa Pacheco Alvarez da Silva, Marcos Yudi Nagaoka Godoy, Jean‐Pierre Timmermans, Cesar Agostinho Ferreira, Tânia Cristina Alexandrino Becker, Erick Guilherme Stoppa, Waldiceu Aparecido Verri, José Ricardo de Arruma Miranda, Juliana Vanessa Colombo Martins Perles, Jacqueline Nelisis Zanoni   +12 more
wiley   +1 more source

Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process

Exploration, Volume 5, Issue 6, December 2025.
Periosteum is a key factor in bone regeneration and repair, and the development of periosteum organoids with the help of organoid technology can achieve accelerated bone regeneration. This review explores the structure and function of the periosteum, the design and application of periosteum organoids, and their potential integration with bone organoids,
Shuyue Hao, Fuxiao Wang, Jingtao Huang, Zhidao Xia, James T. Triffitt, Chenjie Xu, Long Bai, Jiacan Su   +7 more
wiley   +1 more source