Results 51 to 60 of about 1,611 (152)
Characterization and use of a rabbit-anti-mouse VPAC1 antibody by flow cytometry [PDF]
Journal of Immunological Methods, 2012 Vasoactive intestinal peptide receptor-1 signaling in lymphocytes has been shown to regulate chemotaxis, proliferation, apoptosis and differentiation. During T cell activation, VPAC1 mRNA is downregulated, but the effect on its protein levels is less clear. A small number of studies have reported measurement of human VPAC1 by flow cytometry, but murine
Rebecca J, Hermann +7 more
openaire +2 more sources
Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway. [PDF]
PLoS ONE, 2013 Pituitary adenylate cyclase activating peptide (PACAP) belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) family. Its action can be mediated by three different receptor subtypes: PAC1, which has exclusive affinity for PACAP, and VPAC1 ...
Tatjana Arsenijevic +6 more
doaj +1 more source
Role of Peptides in Skeletal Muscle Wasting: A Scoping Review
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive functions, positioning them
Petar Naumovski +9 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2021 Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal polypeptide (VIP)-the secretin-glucagon family of neuropeptides. They act through two classes of receptors: PACAP type 1 (PAC1) and type 2 (VPAC1 and VPAC2)
Jérôme Ruel +8 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Neurogastroenterology &Motility, Volume 37, Issue 12, December 2025.3D imaging of nerve fibers and mast cells double‐labeled with antibodies against Substance P (SP, red) and tryptase (green) on CLARITY‐cleared human sigmoid colonic mucosal biopsies from an IBS patient. (A). Their spatial proximity was computationally quantified using Imaris 9.7 software (B), which demonstrated a significant positive correlation with ...
Pu‐Qing Yuan +7 more
wiley +1 more source
Frontiers in Endocrinology, 2012 VIP plays diverse and important role in human physiology and physiopathology and their receptors constitute potential targets for the treatment of several diseases such as neurodegenerative disorder, asthma, diabetes and inflammatory diseases.
Ingrid eLanger
doaj +1 more source
Immunity, Inflammation and Disease, 2023 Introduction Sjögren's disease (SjD) is a chronic autoimmune disease characterized by the loss of the secretory function of the exocrine glands. At present, drugs that can both correct the immune imbalance and improve exocrine gland function are needed ...
Yixi Li +4 more
doaj +1 more source
Biomedicines, 2021 We aimed to evaluate the direct action of VIP on crucial molecules involved in human osteoclast differentiation and function. We also investigated the relationship between VIP serum levels and bone remodeling mediators in early arthritis patients.
David Castro-Vazquez +11 more
doaj +1 more source
Advanced Healthcare Materials, Volume 14, Issue 24, September 18, 2025.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source