Results 61 to 70 of about 1,611 (152)
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, Volume 3, Issue 3, September 2025.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Biochemical and Functional Interaction between VPAC1 and S‐SCAM/MAGI‐2
The FASEB Journal, 2007 The vasoactive intestinal peptide (VIP) is 28 amino acid neuropeptide which has a wide distribution in peripheral and central nervous systems and a large spectrum of biological actions in mammals.
Heon Yung Gee +6 more
openaire +1 more source
MedComm, Volume 6, Issue 7, July 2025.A brief view of possible etiologic events preceding the diagnosis of desiccation syndrome. ABSTRACT Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by T‐cell‐mediated B‐cell hyperactivity and cytokine production, clinically manifesting, dry mouth and eyes, accompanied by pain and fatigue.
Ying Hu +8 more
wiley +1 more source
Preliminary Study of Radioiodination of VP2
Journal of Isotopes, 2016 The VP2 peptide specifically binding to vasoactive intestinal polypeptide receptor 1(VPAC1) receptor was radioiodinated with 131I by bi-functional linker N-succinimidyl 5-(tributylstannyl)-3-pyridinecarboxylate (SPC), and in vitro and in vivo stability ...
MA Huan +5 more
doaj +1 more source
Neuropsychopharmacology Reports, Volume 45, Issue 1, March 2025.PACAP‐6‐38, a PAC1R‐selective antagonist, was injected into the hippocampus of Sprague–Dawley rats to assess its effect on anxiety‐like behavior. The results showed that the drug led to increased time spent in the open arm of the elevated plus‐maze, indicating an anxiolytic effect.
Kaito Sato +5 more
wiley +1 more source
An Overview of VPAC Receptors in Rheumatoid Arthritis: Biological Role and Clinical Significance
Frontiers in Endocrinology, 2019 The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins.
Rosa P. Gomariz +9 more
doaj +1 more source
Journal of Neuroendocrinology, Volume 37, Issue 3, March 2025.The thera(g)nostic approach with somatostatin analog‐based agents extends beyond gastroenteropancreatic neuroendocrine tumors. Understanding tumor biological mechanisms is essential for optimizing treatment strategies. Abstract First isolated by Brazeau et al. in 1972, somatostatin (SST) is a neuropeptide known for regulating various signaling pathways
Giulia Santo +3 more
wiley +1 more source
Neuropeptide Receptors: Novel Targets for HIV/AIDS Therapeutics
Pharmaceuticals, 2011 The vasoactive intestinal peptide/pituitary adenylyl cyclase-activating polypepetide (VPAC) receptors are important for many physiologic functions, including glucose homeostasis, neuroprotection, memory, gut function, modulation of the immune system and ...
Donald R. Branch
doaj +1 more source
Frontiers in Cellular Neuroscience, 2020 Cognitive impairment is one of the major symptoms in most neurodegenerative disorders such as Alzheimer’s (AD), Parkinson (PD), and Huntington diseases (HD), affecting millions of people worldwide.
Irene Solés-Tarrés +3 more
doaj +1 more source