Results 71 to 80 of about 1,611 (152)
The role of amphipathic and cationic helical peptides in Parkinson's disease
Protein Science, Volume 34, Issue 1, January 2025.Abstract Peptides are attracting a growing interest for therapeutic applications in biomedicine. In Parkinson's disease (PD), different human endogenous peptides have been associated with beneficial effects, including protein aggregation inhibition, reduced inflammation, or the protection of dopaminergic neurons.
Carlos Pintado‐Grima, Salvador Ventura
wiley +1 more source
International Journal of Genomics, Volume 2025, Issue 1, 2025.This study investigates the promoter region and regulatory elements of chicken insulin‐like growth factor (IGF) and vasoactive intestinal polypeptide (VIP) genes associated with reproductive traits. Several in silico tools, such as Neural Network Promoter Prediction (NNPP), Multiple Expectation maximizations for Motif Elicitation (MEME‐Suite), GC ...
Bosenu Abera +4 more
wiley +1 more source
Neural control of coronary artery blood flow by non‐adrenergic and non‐cholinergic mechanisms
Experimental Physiology, Volume 109, Issue 12, Page 2011-2016, 1 December 2024.Abstract Blood flow through the coronary vasculature is essential to maintain myocardial function. As the metabolic demand of the heart increases, so does blood flow through the coronary arteries in a dynamic and adaptive manner. Several mechanisms, including local metabolic factors, mechanical forces and autonomic neural control, regulate coronary ...
Julia Shanks +2 more
wiley +1 more source
VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression [PDF]
, 2018 AbstractAlthough VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal physiology, their involvements in progression of gastrointestinal tumor have not been explored. Here, we found that higher expression of VIP/VPAC1 was observed in gastric cancer compared to the adjacent normal tissues. The increased expression of
Tang, Bo +10 more
openaire +1 more source
Ikaros engages the VPAC1 promoter and recruits HDAC1 in activated HuT78 cells
The FASEB Journal, 2010 Proper regulation of the anti‐proliferative G Protein coupled receptor vasoactive intestinal peptide receptor 1 (VPAC1) is important for normal lymphocyte function. VPAC1 mRNA levels are dependent on the activation status of CD4 T cells, as TCR signaling downregulates VPAC1 expression.
Keith D Benton +4 more
openaire +1 more source
Frontiers in Cellular and Infection Microbiology, 2019 Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide with distinct functions including the regulation of inflammatory processes.
Caio Andreeta Figueiredo +9 more
doaj +1 more source
The Human VPAC1 Receptor [PDF]
Journal of Biological Chemistry, 2001 Laurence Lins +8 more
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Genomics, 1999 The gene encoding the mouse vasoactive intestinal polypeptide type 1 (VPAC1) receptor was cloned, and its structural organization was determined. The gene (Vipr1) is more than 16 kb in length and is divided into 13 exons. The 5'-flanking region is highly GC-rich and lacks an apparent TATA box, but contains a CCAAT box, three potential Sp1-binding sites,
H, Hashimoto +10 more
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OncoImmunology, 2017 Vasoactive intestinal peptide (VIP) is a neuroendocrine peptide hormone that has potent anti-inflammatory activities. VIP signaling through its receptor VPAC1 on T cells leads to reduced proliferation and a reduction in pro-inflammatory cytokine ...
Christopher T. Petersen +2 more
doaj +1 more source
Human VPAC1 Receptor Selectivity Filter [PDF]
Journal of Biological Chemistry, 2002 Kai Du +4 more
openaire +1 more source