Results 81 to 90 of about 1,611 (152)

An Inhibitor Against CKII Phosphorylation Downregulates VPAC1 Expression in HuT‐78 Cells

The FASEB Journal, 2010
Presently, Leukemia affects about 250,000 people in America and it is expected that 45,000 new cases will be diagnosed in 2009. We have previously published that Ikaros (IK), a tumor suppressor, downregulates vasoactive intestinal receptor 1 (VPAC1), an anti‐proliferative G protein coupled receptor, mediated by
Ashley Marie Nelson, Keith Benton, Rebecca Hermann, Travis Van der Steen, Glenn Dorsam   +4 more
openaire   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide Protects Glomerular Podocytes from Inflammatory Injuries

Journal of Diabetes Research, 2015
Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease; however, there are few treatment options. Inflammation plays a crucial role in the initiation and/or progression of DN.
Kenichi Sakamoto, Kyoko Kuno, Minoru Takemoto, Peng He, Takahiro Ishikawa, Shunichiro Onishi, Ryoichi Ishibashi, Emiko Okabe, Mayumi Shoji, Akiko Hattori, Masaya Yamaga, Kazuki Kobayashi, Harukiyo Kawamura, Hirotake Tokuyama, Yoshiro Maezawa, Koutaro Yokote   +15 more
doaj   +1 more source

Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration

Frontiers in Neuroscience, 2019
Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylyl Cyclase Activating Peptide (PACAP) are regeneration-associated neuropeptides, which are up-regulated by neurons following peripheral nerve injury.
Patricia K. Woodley, Qing Min, Yankun Li, Nina F. Mulvey, David B. Parkinson, Xin-peng Dun, Xin-peng Dun, Xin-peng Dun   +7 more
doaj   +1 more source

PACAP and its receptors in cranial arteries and mast cells

The Journal of Headache and Pain, 2018
Background In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells.
Inger Jansen-Olesen, Sara Hougaard Pedersen   +1 more
doaj   +1 more source

Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions

Frontiers in Neural Circuits, 2012
GABAergic interneurons are local integrators of cortical activity that have been reported to be involved in the control of cerebral blood flow through their ability to produce vasoactive molecules and their rich innervation of neighboring blood vessels ...
Quentin ePerrenoud, Jean eRossier, Isabelle eFérézou, Hélène eGeoffroy, Thierry eGallopin, Tania eVitalis, Armelle eRancillac   +6 more
doaj   +1 more source

Augmented cystine–glutamate exchange by pituitary adenylate cyclase‐activating polypeptide signaling via the VPAC1 receptor

Synapse, 2014
ABSTRACTIn the central nervous system, cystine import in exchange for glutamate through system is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system activity affects multiple aspects of cellular physiology and may contribute to disease ...
Resch, Jon M., Albano, Rebecca, Liu, Xiaoqian, Hjelmhaug, Julie, Lobner, Doug, Baker, David A., Choi, Sujean   +6 more
openaire   +3 more sources

Spatiotemporal Remodeling of Enteric Neural Pathways Underlies Colonic Dysmotility Following Spinal Cord Injury in Rats. [PDF]

J Neurogastroenterol Motil
Kim MS, Kim S, Ha SE, Choi HS, Yu MH, You J, Seon D, Lee DH, Joo MC, Kim YS, Choi SC, Kwon JG, Park KS, Kim HJ, Ro S, Lee MY.   +15 more
europepmc   +1 more source

Neuropeptide GPCRs in neuroendocrinology: The case of Activity-Dependent Neuroprotective Protein (ADNP)

Frontiers in Endocrinology, 2012
Illana eGozes
doaj   +1 more source

PACAP versus CGRP in migraine: From mouse models to clinical translation. [PDF]

Cephalalgia
Pietra AD, Kuburas A, Russo AF.
europepmc   +1 more source

Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma. [PDF]

Eur Respir Rev
Koster CS, Lavitola C, Teodorescu R, Bakker BA, Gosens R.   +4 more
europepmc   +1 more source