Results 151 to 160 of about 16,455 (176)
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Inhibition of prokaryotic cell growth by HIV1 Vpr
Research in Virology, 1997We have cloned the nef, vif, vpr and vpu genes of HIV1 in the pGEX system to produce auxiliary proteins of HIV1 as N-terminal fusions with glutathione S-transferase (GST). Some GST proteins are difficult to obtain under standard conditions. The synthesis and solubility varied considerably from one protein to another. We investigated the reasons for the
M, Bodéus +4 more
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Cytocidal activities of hiv-1 vpr are shared by primate lentivirus vpr and vpx relatives
Protein & Peptide Letters, 1998Abstract: The ability of HIV-1 Vpr to kill human cells has been shown to be due to the sequence, HFRIGCRHSRIG, comprising Vpr amino acid residues 71-82. In this study cell killing by Vpr equivalents in other primate lentiviruses has been examined. Five purified synthetic peptides, related to the bioactive region ofHIV-1 Vpr and derived from HIV-2 Vpr ...
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Structure-Function Relationship of Vpr: Biological Implications
Current HIV Research, 2009Vpr, incorporated into the HIV-1 virion, shows multiple activities including nuclear transport of the preintegration complex to the nucleus, activation of the transcription, cell cycle arrest at the G2/M transition and induction of apoptosis. Vpr controls many host cell functions through a variety of biological activities and by interaction with ...
Morellet, Nelly +2 more
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Effects of HIV-1 Vpr on Neuroinvasion and Neuropathogenesis
DNA and Cell Biology, 2004Human immunodeficiency virus type I (HIV-1) infection leads to penetration of the central nervous system (CNS) in virtually all infected individuals and HIV-1–induced encephalopathy in a significant number of untreated patients. The molecular mechanisms by which HIV-1 enters the CNS and yields CNS dysfunction are still unclear.
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HIV-1 Vpr-induced cell death in Schizosaccharomyces pombe is reminiscent of apoptosis
Cell Research, 2008Mingzhong Chen +2 more
exaly
Differential apoptosis effects of primate lentiviral Vpr and Vpx in mammalian cells
Journal of Biomedical Science, 2000Lung-Ji Chang, Chang Lung-Ji
exaly