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Operating CRISPR/Cas12a in a complex nucleic acid sequence background. [PDF]
Nucleic Acids ResHellmer H +3 more
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In Situ Vaccination with a Vpr-Derived Peptide Elicits Systemic Antitumor Immunity by Improving Tumor Immunogenicity. [PDF]
Vaccines (Basel)Pan D +12 more
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Biomedicine and Pharmacotherapy, 2003 Vpr, a 14-kDa, 96 amino acid protein, is conserved among the primate lentiviruses HIV-1, HIV-2 and Simian Immunodeficiency virus supporting the notion that it plays an important role in virus life cycle in vivo. Vpr appears to have several functions including cell cycle arrest at G2 stage, apoptosis, nuclear localization, nuclear import of the pre ...
Bassel E Sawaya +2 more
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The Role of Vpr in HIV-1 Pathogenesis
Current HIV Research, 2005The HIV-1 vpr gene is conserved among the human (HIV-1, HIV-2) and simian immunodeficiency viruses (SIV). HIV-1 vpr encodes a 96-amino acid, 14 kDa protein (Vpr). Research from a number of laboratories in the last decade has shown that Vpr performs multiple functions, including the induction of cell cycle arrest in the G(2) phase, transactivation of ...
Vicente Planelles, Planelles Vicente
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Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr
Virology, 2015 Vpr and Vpx are a group of highly related accessory proteins from primate lentiviruses. Despite the high degree of amino acid homology within this group, these proteins can be highly divergent in their functions. In this work, we constructed chimeric and mutant proteins between HIV-1 and SIVagm Vpr in order to better understand the structure-function ...
Ana BEATRIZ Depaula-Silva +2 more
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Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity—absence of VPRs in sheep liver
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 19931. We have studied the binding characteristics of the hepatic VPRs expressed by rat, cow, pig, sheep and human and have demonstrated species heterogeneity. 2. These species differences are manifested as variation in the VPR capacity (rat > cow > pig > human > sheep), and in the affinity of these receptors for their natural ligand AVP (rat = human > pig
J, Howl, M, Wheatley
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2021
O início dos anos 60 na América Latina foi marcado, no aspecto político, pela Revolução Cubana, a qual ocorreu em plena Guerra Fria. Os acontecimentos em Cuba abalaram profundamente a estabilidade política do continente, além de terem afetado a política mundial, principalmente no momento da instalação dos mísseis nucleares em Cuba, correndo o risco do ...
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O início dos anos 60 na América Latina foi marcado, no aspecto político, pela Revolução Cubana, a qual ocorreu em plena Guerra Fria. Os acontecimentos em Cuba abalaram profundamente a estabilidade política do continente, além de terem afetado a política mundial, principalmente no momento da instalação dos mísseis nucleares em Cuba, correndo o risco do ...
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Murine Models of Vpr-Mediated Pathogenesis
Current HIV Research, 2009HIV viral protein r (Vpr) exerts a variety of cellular effects, including modulation of transcription and cytokine production, apoptosis, and cell cycle arrest. Vpr induces these affects by mechanisms that include inhibition of NF-kappaB activation, inducing mitochondrial injury, and promoting proteasomal degradation of cellular factor(s) leading to ...
Alexandra, Snyder, Michael J, Ross
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The vpr Regulatory Gene of HIV
1995Virus replication is the result of a series of two-way communications between the viral parasite and its host. Since viruses are essentially inert objects in the absence of a host cell, all aspects of their natural history can be defined in terms of these interactions.
D N, Levy, Y, Refaeli, D B, Weiner
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Upregulation of survivin by HIV-1 Vpr
Apoptosis, 2003The human survivin gene belongs to the family of inhibitor of apoptosis proteins (IAP) and is involved in apoptosis inhibition and regulation of cell division. The survivin gene is the only member of the IAP family whose expression is known to be regulated through the cell cycle.
Y, Zhu +4 more
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